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학술저널
저자정보
Tang, Min (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) Hou, Yan-Li (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) Kang, Qiang-Qiang (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) Chen, Xing-Yue (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) Duan, Li-Qun (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) Shu, Jin (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) Li, Shao-Lin (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University) Hu, Xiao-Li (Department of Nuclear Medical, The First Affiliated Hospital, Chongqing Medical University) Peng, Zhi-Ping (Department of Radiation Medicine, The First Affiliated Hospital, Chongqing Medical University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제4호
발행연도
2014.1
수록면
1,859 - 1,862 (4page)

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Recently, the main therapy of medullary thyroid cancer (MTC) is surgical, but by which way there is a poor prognosis with a mean survival of only 5 years. In some cases, some researchers found that it is the medullary thyroid cancer stem cells (MTCSCs) that cause metastasis and recurrence. This study aimed to eradicate MTCSCs through administration of all-trans-retinoic acid (ATRA). Here we demonstrate that MTCSCs possess stemlike properties in serum-free medium. The ABCG2, OCT4 and sodium iodide symporter (NIS) were changed by ATRA. Additionally, we found that ATRA can increase the expression of NIS in vivo. All the data suggested that ATRA could increase the iodine uptake of MTCSCs through NIS.

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