Clinical Manifestations and Imaging Characteristics of Gliomatosis Cerebri with Pathological Confirmation

Zhang, Chun-Pu; Li, Hua-Qing; Zhang, Wei-Tao; Liu, Ming-Hui; Pan, Wen-Jing

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자료유형: 학술저널

저자정보: Zhang, Chun-Pu (Department of Neurosurgery, Affiliated Hospital of Taishan Medical University) Li, Hua-Qing (ICU, Affiliated Hospital of Taishan Medical University) Zhang, Wei-Tao (Department of Otolaryngology, Central Hospital, Shangdong Energy Feicheng Mining Group Co. Ltd.) Liu, Ming-Hui (Central Hospital, Shangdong Energy Feicheng Mining Group Co. Ltd.) Pan, Wen-Jing (ICU, Affiliated Hospital of Taishan Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제11호

발행연도: 2014.1

수록면: 4,487 - 4,491 (5page)

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Objective: To explore the clinical manifestations and imaging characteristics of gliomatosis cerebri to raise the awareness and improve its diagnostic accuracy for patients. Materials and Methods: Clinical data, imaging characteristics and pathological examination of 12 patients with GC from Jan., 2008 to Jan., 2012 were analyzed retrospectively. Results: Patients with GC were clinically manifested with headache, vomiting, repeated seizures, fatigue and unstable walking, most of whom had more than 2 lesions involving in parietal lobe, followed by temporal lobe, frontal lobe, periventricular white matter and corpus callosum. Magnetic resonance imaging (MRI) showed diffuse distribution, T1-weighted images (T1WI) with equal and low signals and T2-weighted images (T2WI) with bilateral symmetrical high diffuse signals. There was no reinforcement by enhancement scanning and signals were different in diffusion-weighted images (DWI). The higher the tumor staging, the stronger the signals. Pathological examination showed neuroastrocytoma in which tumor tissues were manifested by infiltrative growth in blood vessels and around neurons. Conclusions: In clinical diagnosis of GC, much attention should be paid to the diffuse distribution of imaging characteristics, incomplete matching between clinical and imaging characteristics and confirmation by combining with histopathological examination.

#Gliomatosis cerebri #clinical manifestation #imaging characteristics #pathological examination

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