Association Between C1019T Polymorphism in the Connexin 37 Gene and Helicobacter Pylori Infection in Patients with Gastric Cancer

Jing, Yuan-Ming; Guo, Su-Xia; Zhang, Xiao-Ping; Sun, Ai-Jing; Tao, Feng; Qian, Hai-Xin

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저자정보: Jing, Yuan-Ming (Department of Gastrointestinal Surgery, Affiliated People's Hospital of Zhejing University in Shaoxing and People's Hospital of Shaoxing City) Guo, Su-Xia (Department of Cardiology, Affiliated People's Hospital of Nanjing Medical University in Wuxi and People's Hospital of Wuxi City) Zhang, Xiao-Ping (Department of Gastrointestinal Surgery, Affiliated People's Hospital of Zhejing University in Shaoxing and People's Hospital of Shaoxing City) Sun, Ai-Jing (Department of Gastrointestinal Surgery, Affiliated People's Hospital of Zhejing University in Shaoxing and People's Hospital of Shaoxing City) Tao, Feng (Department of Gastrointestinal Surgery, Affiliated People's Hospital of Zhejing University in Shaoxing and People's Hospital of Shaoxing City) Qian, Hai-Xin (Department of General Surgery, The First Affiliated Hospital of Soochow University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호

발행연도: 2012.1

수록면: 2,363 - 2,367 (5page)

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Objective: To investigate the association between the connexin 37 C1019T polymorphism and Helicobacter pylori infection in patients with gastric cancer. Methods: 388 patients with gastric cancer (GC), 204 with chronic superficial gastritis (CSG) were studied. H. pylori was detected by gastric mucosal biopsies biopsy dyeing method. Connexin 37 gene polymorphism 1019 site genotypes were determined by gene sequencing technology. Genotypes and alleles frequencies were compared. Results: (1) Connexin37 gene 1019 site distribution frequency (CC type, TC type, TT type) in the CSG group was 18.1%, 45.1% and 36.8%; in the stomach cancer group it was 35.1%, 45.9% and 19.%, conforming to the Hardy-Weinberg euilibrium. (2) In comparison with CSG group, the frequency of Connexin37 C allele was higher in the gastric cancer group (58.0% vs 40.7%, OR = 2.01, 95%CI = 1.58-2.57, P < 0.01). The prevalence of gastric cancer risk was significantly increased in the carriers of C allele (CC+TC) than in TT homozygote (OR = 2.47, 5%CI = 1.68- 3.610. (3) Gastric cancer patients complicated with Hp infection 211 cases, gastric cancer group of the male patients with HP positive patients with 187 cases, 40 cases of female patients with negative patients, 24 cases were HP positive, negative in 137 cases, control group male patients, 28 cases were Hp positive, negative in 95 patients, female patients with Hp positive 6 cases, 75 cases were negative. On hierarchical analysis, the male group OR value was 15.9 (95%CI to 9.22-27.3), and the female OR was 2.19 (95%CI 0.88-5.59), indicating a greater contribution in males (P <0.01). After elimination of gender effects, positive HP and gastric cancer were closely related (OR 8.82, 95% CI: 5.45-14.3). (4) The distribution frequency of C allele in patients with Hp infection was much higher than that in Hp negative cases in the GC group (64.5% vs 47.0%, OR = 2.05, 95%CI = 1.54-2.74, P < 0.01). Compared with TT homozygotes, (CC+TC) genotype prevalence of gastric cancer risk increased significantly (OR = 2.96, 5%CI = 1.76-2.99 ). Conclusion: The T allele in the connexin37 gene might not only be associated with gastric cancer but also with H. pylori infection.

#Stomach neoplasms #Helicobacter pylori #connexin 37 C1019T #polymorphism #risk factor

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Jing, Yuan-Ming

소속기관 Department of Gastrointestinal Surgery, Affiliated People's Hospital of Zhejing University in Shaoxi