Association Between the FAS/FASL Polymorphisms and Gastric Cancer Risk: A Meta-Analysis

Tian, Jing; Pan, Feng; Li, Jing; Ma, Yan; Cen, Han; Pan, Hai-Feng; Pan, Yue-Yin; Ye, Dong-Qing

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자료유형: 학술저널

저자정보: Tian, Jing (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) Pan, Feng (Department of Oncology, The First Affiliated Hospital of Anhui Medical University) Li, Jing (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) Ma, Yan (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) Cen, Han (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) Pan, Hai-Feng (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) Pan, Yue-Yin (Department of Oncology, The First Affiliated Hospital of Anhui Medical University) Ye, Dong-Qing (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제3호

발행연도: 2012.1

수록면: 945 - 951 (7page)

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Objective: FAS/FASL gene promoter polymorphisms have been repeatedly associated with gastric cancer risk, but findings are inconclusive across studies. To address a more precise estimation of the relationship, a meta-analysis was performed. Methods: Data were collected from the Pubmed, Medline and EMBASE databases, with the last report up to 1 December, 2011. Crude ORs with 95% CIs were used to assess the strength of the association by (1) the additive, (2) the codominant, (3) the dominant, and (4) the recessive models. Results: A total of seven studies, including six studies on FAS -1377G>A polymorphism, five studies on FAS -670A>G polymorphism, and six studies on FASL -844T>C polymorphism, were identified in the current meta-analysis. Overall, an association of FAS -1377G>A (AA versus GG: OR = 1.313, 95% CI = 1.045-1.650, Ph = 0.347, $I^2$ = 10.8) and FASL -844T>C (CC versus TT: OR = 1.352, 95% CI = 1.043-1.752, Ph = 0.461, $I^2$ = 0.0) polymorphisms with gastric cancer was found in the codominant model. However, we did not detect any association between gastric cancer and the FAS -670A>G polymorphism. In the subgroup analysis by ethnicity, similar elevated risks were also observed in Asian population for FAS -1377G>A (AA versus GG: OR = 1.309, 95% CI = 1.041-1.646, Ph = 0.240, $I^2$ = 27.3) and FASL -844T>C (CC versus TT: OR = 1.420, 95% CI = 1.081-1.865, Ph = 0.524, $I^2$ = 0.0) polymorphisms. Conclusions: This meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk.

#Gastric cancer #FAS #FASL #polymorphism #meta-analysis

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