지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제45권 제4호
- 발행연도
- 2011.1
- 수록면
- 248 - 254 (7page)
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초록· 키워드
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Background Clinafloxacin dithiocarbamate (CNND) was radiolabeled with technetium-99m ($^{99m}Tc$) using $[^{99m}Tc(CO){_3}(H_2O){_3}]^+$ and assessed for its radiochemical stability in saline and serum, its in vitro binding with methicillinresistant Staphylococcus aureus (MRSA) and biodistribution in female nude mice (FNM) artificially infected with live and heat-killed MRSA. Methods In normal saline (NS) the $^{99m}Tc(CO){_3}$-clinafloxacin dithiocarbamate ($^{99m}Tc(CO){_3}$-CNND) showed radiochemical stability with a maximum value of $99.10{\pm}0.20%$ and remained stable up to 4 h ($92.65{\pm}0.18%$). Results In human serum at $37^{\circ}C$ within 16 h of incubation, 14.85% side products as a result of de-tagging developed. Incubation with MRSA gave saturated binding with a maximum value of $72.75{\pm}1.20%$. Almost six-fold higher uptake was seen in the infected muscle of the FNM as compared to the inflamed and normal muscle. The $^{99m}Tc(CO){_3}$-CNND complex showed a normal route of excretion from the body of the FNM model. Conclusion The higher stability in NS, HS, saturated in vitro binding with a live strain ofMRSA and six-fold higher uptake in the target organ showed the $^{99m}Tc(CO){_3}$-CNND complex to be a potential MRSA infection radiotracer.
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