지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective : Alcoholic neuropathy is characterized by allodynia (a discomfort evoked by normally innocuous stimuli), hyperalgesia (an exaggerated pain in response to painful stimuli) and spontaneous burning pain. The aim of the present study is to investigate the effect of rolipram, a phosphodiesterase 4 inhibitor, against alcohol-induced neuropathy in rats. Methods : Allodynia was induced by administering 35% v/v ethanol (10 g/kg; oral gavage) to Spraue-Dawley rats for 8 weeks. Rolipram and saline (vehicle) were administered intraperitoneally. Mechanical allodynia was measured by using von Frey filaments. Somatosensory evoked potential (SEP) was proposed as complementary measure to assess the integrity of nerve pathway. Results : The ethanol-induced mechanical allodynia began to manifest from 3 week, and then peaked within 1 week. Beginning from 3 week, latency significantly started to increased in control group. In rolipram treated rats, the shorter latency was sustained until 8 weeks (p<0.05). The mechanical allodynia, which began to manifest on the 3 weeks, intraperitoneal injections of rolipram sustained statistical difference until 8 weeks, the final week of the study (p<0.05). Conclusion : This study suggests that rolipram might alleviate mechanical allodynia induced by alcohol in rats, which clearly has clinical implication.
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참고문헌 (35)
참고문헌 신청
Atkins CM / 2007 / Modulation of the cAMP signaling pathway after traumatic brain injury / Exp Neurol 208:145~158
Bosch EP / 1979 / Animal models of alcoholic neuropathy : morphologic, electrophysiologic, and biochemical findings / Muscle Nerve 2:133~144
Brain WR / 1969 / Disorders of peripheral nerves : alcoholoc polyneuritis. Brain’s deseases of the nervous system, 7th ed / Oxford :817~819
Cogswell JP / 1994 / NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site / J Immunol 153:712~723
Corsetti G / 1998 / Ultrastructural study of the alterations in spinal ganglion cells of rats chronically fed on ethanol / Ultrastruct Pathol 22:309~319
Bosch EP / 1979 / Animal models of alcoholic neuropathy : morphologic, electrophysiologic, and biochemical findings / Muscle Nerve 2:133~144
Brain WR / 1969 / Disorders of peripheral nerves : alcoholoc polyneuritis. Brain’s deseases of the nervous system, 7th ed / Oxford :817~819
Cogswell JP / 1994 / NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site / J Immunol 153:712~723
Corsetti G / 1998 / Ultrastructural study of the alterations in spinal ganglion cells of rats chronically fed on ethanol / Ultrastruct Pathol 22:309~319
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