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논문 기본 정보

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학술저널
저자정보
Gwak, Ho-Shin (Department of Neuro-Oncology Clinic, National Cancer Center) Park, Hyeon-Jin (Center for Pediatric Oncology, National Cancer Center) Yoo, Heon (Department of Neuro-Oncology Clinic, National Cancer Center) Youn, Sang-Min (Department of Neurosurgery, Korea Institute of Radiological and Medical Science) Rhee, Chang-Hun (Department of Neurosurgery, Korea Institute of Radiological and Medical Science) Lee, Seung-Hoon (Department of Neuro-Oncology Clinic, National Cancer Center)
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대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제50권 제5호
발행연도
2011.1
수록면
426 - 433 (8page)

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Objective : The Histoculture Drug Response Assay (HDRA), which measures chemosensitivity using minced tumor tissue on drug-soaked gelfoam, has been expected to overcome the limitations of in vitro chemosensitivity test in part. We analyzed interim results of HDRA in malignant gliomas to see if the test can deserve further clinical trials. Methods : Thirty-three patients with malignant gliomas were operated and their tumor samples were examined for the chemosensitivity to 10 chosen drugs by HDRA. The most sensitive chemotherapy regimen among those pre-established was chosen based on the number of sensitive drugs or total inhibition rate (IR) of the regimen. The response was evaluated by 3 month magnetic resonance image. Results : Among 13 patients who underwent total resection of the tumor, 12 showed no evidence of disease and one patient revealed progression. The response rate in 20 patients with residual tumors was 55% (3 complete and 8 partial responses). HDRA sensitivity at the cut-off value of more than one sensitive drug in the applied regimen showed a sensitivity of 100%, specificity of 60% and predictability of 70%. Another cut-off value of >80% of total IR revealed a sensitivity of 100%, specificity of 69%, and predictability of 80%. For 12 newly diagnosed glioblastoma patients, median progression-free survival of the HDRA sensitive group was 21 months, while that of the non-sensitive group was 6 months ($p$=0.07). Conclusion : HDRA for malignant glioma was inferred as a feasible method to predict the chemotherapy response. We are encouraged to launch phase 2 clinical trial with chemosensitivity on HDRA.
#Chemotherapy #Drug sensitivity tests #Malignant glioma

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참고문헌 (49)

참고문헌 신청
Andreotti PE / 1995 / Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay : clinical correlation for cisplatin resistance of ovarian carcinoma / Cancer Res 55:5276~5282 google schola Bogdahn U / 1983 / Chemosensitivity of malignant human brain tumors. Preliminary results / J Neurooncol 1:149~166 google schola Boiardi A / 2000 / Cisplatin and BCNU chemotherapy for anaplastic oligoastrocytomas / J Neurooncol 49:71~75 google schola Choi IS / 2002 / Phase II study of chemotherapy with ACNU plus cisplatin followed by cranial irradiation in patients with newly diagnosed glioblastoma multiforme / J Neurooncol 60:171~176 google schola Fine HA / 1993 / Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults / Cancer 71:2585~2597 google schola

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