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논문 기본 정보

자료유형
학술저널
저자정보
Choi, Man Kyu (Department of Neurosurgery, College of Medicine, Kyung Hee University) Kim, Sung Bum (Department of Neurosurgery, College of Medicine, Kyung Hee University) Kim, Kee D. (Department of Neurosurgery, University of California Davis) Ament, Jared D. (Department of Neurosurgery, University of California Davis)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제56권 제3호
발행연도
2014.1
수록면
218 - 223 (6page)

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Objective : C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are often utilized to evaluate for postoperative infection. Abnormal values may be detected after surgery even in case of non-infection because of muscle injury, transfusion, which disturbed prompt perioperative management. The purpose of this study was to evaluate and compare the perioperative CRP, ESR, and white blood cell (WBC) counts after spine surgery, which was proved to be non-infection. Methods : Twenty patients of lumbar open discectomy (LOD) and 20 patients of posterior lumbar interbody fusion (PLIF) were enrolled in this study. Preoperative and postoperative prophylactic antibiotics were administered routinely for 7 days. Blood samples were obtained one day before surgery and postoperative day (POD) 1, POD3, and POD7. Using repeated measures ANOVA, changes in effect measures over time and between groups over time were assessed. All data analysis was conducted using SAS v.9.1. Results : Changes in CRP, within treatment groups over time and between treatment groups over time were both statistically significant F(3,120)=5.05, p=0.003 and F(1,39)=7.46, p=0.01, respectively. Most dramatic changes were decreases in the LOD group on POD3 and POD7. Changes in ESR, within treatment groups over time and between treatment groups over time were also found to be statistically significant, F(3,120)=6.67, p=0.0003 and F(1,39)=3.99, p=0.01, respectively. Changes in WBC values also were be statistically significant within groups over time, F(3,120)=40.52, p<0.001, however, no significant difference was found in between groups WBC levels over time, F(1,39)=0.02, p=0.89. Conclusion : We found that, dramatic decrease of CRP was detected on POD3 and POD7 in LOD group of non-infection and dramatic increase of ESR on POD3 and POD7 in PLIF group of non-infection. We also assumed that CRP would be more effective and sensitive parameter especially in LOD than PLIF for early detection of infectious complications. Awareness of the typical pattern of CRP, ESR, and WBC may help to evaluate the early postoperative course.
#Open discectomy #Posterior lumbar interbody fusion #Postoperative infection #C-reactive protein #Erythrocyte sedimentation rate #White blood cell

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참고문헌 (20)

참고문헌 신청
Black S / 2004 / C-reactive Protein / J Biol Chem 279:48487~48490 google schola Yeon Gu Chung / 2011 / Comparison of Serum CRP and Procalcitonin in Patients after Spine Surgery / 대한신경외과학회지 49(1):43~48 google schola Clyne B / 1999 / The C-reactive protein / J Emerg Med 17:1019~1025 google schola Enright H / 1990 / C-reactive protein concentrations pre- and post-transfusion / Clin Lab Haematol 12:25~29 google schola Gelalis ID / 2011 / Bacterial wound contamination during simple and complex spinal procedures. A prospective clinical study / Spine J 11:1042~1048 google schola

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