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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 107 - 116 (10page)
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The global obesity epidemic and associated metabolic diseases require alternative biological targets for new therapeutic strategies. In this study, we show that a phytochemical sulfuretin suppressed adipocyte differentiation of preadipocytes and administration of sulfuretin to high fat diet-fed obese mice prevented obesity and increased insulin sensitivity. These effects were associated with a suppressed expression of inflammatory markers, induced expression of adiponectin, and increased levels of phosphorylated ERK and AKT. To elucidate the molecular mechanism of sulfuretin in adipocytes, we performed microarray analysis and identified activating transcription factor 3 (Atf3) as a sulfuretin-responsive gene. Sulfuretin elevated Atf3 mRNA and protein levels in white adipose tissue and adipocytes. Consistently, deficiency of Atf3 promoted lipid accumulation and the expression of adipocyte markers. Sulfuretin's but not resveratrol's anti-adipogenic effects were diminished in Atf3 deficient cells, indicating that Atf3 is an essential factor in the effects of sulfuretin. These results highlight the usefulness of sulfuretin as a new anti-obesity intervention for the prevention of obesity and its associated metabolic diseases.
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참고문헌 (37)
참고문헌 신청
Auh QS / 2016 / Sulfuretin promotes osteoblastic differentiation in primary cultured osteoblasts and in vivo bone healing / Oncotarget 7:78320~78330
Ding S / 2004 / A role for chemistry in stem cell biology / Nat. Biotechnol 22:833~840
Favre D / 2011 / Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesity / Diabetes 60:3169~3174
Graham DJ / 2010 / Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone / JAMA 304:411~418
Hai T / 2010 / ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases : is modulation of inflammation a unifying component? / Gene. Expr 15:1~11
Ding S / 2004 / A role for chemistry in stem cell biology / Nat. Biotechnol 22:833~840
Favre D / 2011 / Impaired expression of the inducible cAMP early repressor accounts for sustained adipose CREB activity in obesity / Diabetes 60:3169~3174
Graham DJ / 2010 / Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazone / JAMA 304:411~418
Hai T / 2010 / ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases : is modulation of inflammation a unifying component? / Gene. Expr 15:1~11
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