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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 99 - 105 (7page)
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초록· 키워드
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Dyslipidemia, mainly characterized by high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, is an important etiological factor in the development of cardiovascular disease (CVD). Considering the relationship between childhood obesity and CVD risk, it would be worthwhile to evaluate whether previously identified lipid-related variants in adult subjects are associated with lipid variations in a childhood obesity study (n = 482). In an association analysis for 16 genome-wide association study (GWAS)-based candidate loci, we confirmed significant associations of a genetic predisposition to lipoprotein concentrations in a childhood obesity study. Having two loci (rs10503669 at LPL and rs16940212 at LIPC) that showed the strongest association with blood levels of TG and HDL-C, we calculated a genetic risk score (GRS), representing the sum of the risk alleles. It has been observed that increasing GRS is significantly associated with decreased HDL-C (effect size, $-1.13{\pm}0.07$) compared to single nucleotide polymorphism combinations without two risk variants. In addition, a positive correlation was observed between allelic dosage score and risk allele (rs10503669 at LPL) on high TG levels (effect size, $10.89{\pm}0.84$). These two loci yielded consistent associations in our previous meta-analysis. Taken together, our findings demonstrate that the genetic architecture of circulating lipid levels (TG and HDL-C) overlap to a large extent in childhood as well as in adulthood. Post-GWAS functional characterization of these variants is further required to elucidate their pathophysiological roles and biological mechanisms.
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참고문헌 (35)
참고문헌 신청
Meagher EA / 2004 / Addressing cardiovascular disease in women: focus on dyslipidemia / J Am Board Fam Pract 17:424~437
Kristiansson K / 2012 / Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits / Circ Cardiovasc Genet 5:242~249
Tan A / 2012 / A genome- wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population / Hum Mol Genet 21:1658~1664
Aulchenko YS / 2009 / Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts / Nat Genet 41:47~55
Kathiresan S / 2008 / Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans / Nat Genet 40:189~197
Kristiansson K / 2012 / Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits / Circ Cardiovasc Genet 5:242~249
Tan A / 2012 / A genome- wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population / Hum Mol Genet 21:1658~1664
Aulchenko YS / 2009 / Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts / Nat Genet 41:47~55
Kathiresan S / 2008 / Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans / Nat Genet 40:189~197
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