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논문 기본 정보

자료유형
학술저널
저자정보
Seo, Byoung-Boo (Dept. of Animal Resources, College of Life & Environmental Science, Daegu University) Park, Hum-Dai (Dept. of Biotechnology, College of Engineering, Daegu University)
저널정보
한국동물번식학회 한국동물번식학회지 한국동물번식학회지 제35권 제4호
발행연도
2011.1
수록면
415 - 420 (6page)

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The experimental manipulation of protooncogenes and their gene products is a valuable research tool for the study of human neoplasia. In this study, the recently identified human cervical cancer protooncogene (HccR-2) was expressed in transgenic mice under the control of the tetracycline regulatory system. Mice expressing the HccR-2 transgene showed an altered myeloid development characterized by an increased percentage of mature and band-form neutrophils in the peripheral blood, liver and spleen. This phenotype is similar to human chronic neutrophilic leukemia (CNL) in many ways, which is a rare chronic myeloproliferative disorder (CMD) that presents as a sustained leukocytosis of mature neutrophils with a few or no circulating immature granulocytes, an absence of peripheral blood monocytosis, basophilia, or eosinophilia, and an infiltration of neutrophils into the liver, spleen and kidney. Thus, the HccR-2 transgenic mouse model is imperative not only for investigating the biological properties of the HccR-2 protooncogene in vivo, but also for analyzing the mechanisms involved in the progression of CNL.

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