지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 75 - 83 (9page)
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초록· 키워드
오류제보하기
Objectives Previous animal studies have shown that mixtures of Cynanchum wilfordii and Phlomis umbrosa extract (IPLUS-CWPU) increases femur length and insulin like growth factor-1 (IGF-1) secretion. IPLUS-CWPU may thus be a promising ingredient in functional foods aimed at growing child's height. The purpose of the study is to investigate the effect of IPLUS-CWPU on height growth in children with short stature. Methods For this purpose, we recruited 90 children aged 4 to 12 years who had heights ranging from the 5th to 25th percentiles of Korean children's growth curve and randomized to either the IPLUS-CWPU or the placebo group. Results The IPLUS-CWPU group showed a significant increase in the change of the height growth compared to the placebo group after 20 weeks of administration (p=0.02). The height growth velosity also showed a statistically significant difference in the test group compared to the placebo group at 10 weeks (p=0.04). The IGF-1 levels showed a tendency to increase in the IPLUS-CWPU group (p=0.08). Moreover, the IPLUS-CWPU significantly increased IGF-1/IGFBP-3 ratio (p=0.02). However, there were no significant differences in blood biochemical parameters including growth hormone, bone age, thyroid stimulating hormone, and osteocalcin levels. Conclusions In conclusion, the data of this trial indicate that IPLUS-CWPU is effective and safe, generally well-tolerated without severe adverse events, in the treatment of children with short stature over a 20 weeks period.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Hong CU / 2016 / Pediatrics / Miraen :2~1204
Rona RJ / 1995 / Genetic and environmental influences on growth / J Med Screen 2(3):133~139
Renard C / 2009 / Genetic and Environmental Factors in Pre- and Postnatal Growth Disorders / Legatron Electronic Publishing :9~200
Kuczmarski RJ / 2000 / CDC Growth Charts for the US / The National Center for Health Statistics 8(314):1~27
김지은 / 2016 / 소아 성장을 위한 한약 투여에 대한 후향적 연구 / 대한한방소아과학회지 30(4):87~98
Rona RJ / 1995 / Genetic and environmental influences on growth / J Med Screen 2(3):133~139
Renard C / 2009 / Genetic and Environmental Factors in Pre- and Postnatal Growth Disorders / Legatron Electronic Publishing :9~200
Kuczmarski RJ / 2000 / CDC Growth Charts for the US / The National Center for Health Statistics 8(314):1~27
김지은 / 2016 / 소아 성장을 위한 한약 투여에 대한 후향적 연구 / 대한한방소아과학회지 30(4):87~98
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