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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Ki-Suk (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) Kim, Shin-Hyung (Kyung Hee Ye Korean Medical Clinic) Jang, Hyeung-Jin (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제11권 제2호
발행연도
2011.1
수록면
113 - 118 (6page)

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$Mori$ $Cortex$ $Radicis$, $Farfarae$ $Flos$, $Asteris$ $Radix$ had been prescribed to treat asthmatic symptoms and help to eliminate sputum in oriental pharmacology, but the anti-inflammatory mechanism of the herbs are not sufficiently defined. Here, we investigated the anti-inflammatory mechanism of the herb 80% ethanol extracts on LPS-induced HMC-1 cells. To determine inhibitory effect of the herb extracts on chronic inflammation, expression of COX-2 and production of pro-inflammatory cytokines IL-6 and TNF-${\alpha}$ were measured. COX-2 expression was downregulated dose-dependently and release of IL-6 and TNF-${\alpha}$ were inhibited by effect of each herb extracts. This study provides information about the cellular mechanism of anti-inflammatory effect of these three herbs extracts which might be helpful to study antiinflammatory agents.

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