지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제11권 제2호
- 발행연도
- 2011.1
- 수록면
- 101 - 106 (6page)
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초록· 키워드
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The objective of the present investigation was to evaluate the therapeutic efficacy of Silymarin in DOCA salt induced hypertension in unilateral nephrectomized rats. Unilateral nephrectomy was performed in female Wistar rats (150-200 g). A week after unilateral nephrectomy, hypertension was induced by DOCA (25 mg/kg, once a week; s.c; for 4 weeks) dispersed in cottonseed oil. The effect of Silymarin (300 mg/kg and 500 mg/kg, p. o., for 4 weeks) was evaluated in DOCA salt induced hypertensive rats. Systolic blood pressure (BP) was measured once every week during the treatment schedule. After completion of treatment schedule, heart rate, arterial blood pressure and vascular reactivity to various drugs were recorded. Rats from individual group were sacrificed, the heart was dissected out and antioxidant enzyme level SOD, CAT, GSH and TBARS were measured. Urine excretions were measured by flame photometer. Silymarin (300, 500 mg/kg/day, p.o.) significantly ($p$ <0.05) reduced systolic blood pressure, heart rate, basal arterial blood pressure and pressor responses to NA, Adr, PE and 5-HT in animals treated with DOCA salt as compared with DOCA-salt hypertensive rats. Silymarin significantly increased antioxidant enzyme level of SOD, CAT, GSH, urinary $Na^+$ excretion and decreased TBARS level, urinary $K^+$ excretion compared with DOCA hypertensive group. Silymarin exhibits significant antihypertensive activity in DOCA salt model of hypertension.
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