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논문 기본 정보

자료유형
학술저널
저자정보
Oh, Sa-Rang (Department of Herbal Medicinal Pharmacology, College of Health and Welfare, Daegu Haany University) Ahn, Eun-Mi (Department of Herbal Foodceutical Science, College of Health and Welfare, Daegu Haany University) Jung, Ji-Wook (Department of Herbal Medicinal Pharmacology, College of Health and Welfare, Daegu Haany University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제11권 제3호
발행연도
2011.1
수록면
199 - 206 (8page)

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$Achyranthus$ $bidentata$ Blume has traditionally been used to treat a variety of diseases including cough, fever, and asthma. However, the anti-amnesic effects of $A.$ $bidentata$ and its molecular mechanisms have yet to be clearly elucidated. In this study, we attempted to evaluate the effects of $A.$ $bidentata$ on scopolamine-induced memory impairments in mice. The regulatory effect of $A.$ $bidentata$ on memory impairment was investigated using passive avoidance, Y-maze and the Morris water maze tasks. Acetylcholinesterase inhibition assay was performed to investigate the cholinergic antagonistic effect of $A.$ $bidentata$ in hippocampus. The result of this study demonstrated that $A.$ $bidentata$ significantly restored memory impairments induced by scopolamine. Increase of Acetylcholinesterase activity caused by scopolamine was significantly attenuated by $A.$ $bidentata$. In addition, $A.$ $bidentata$ recovered the reduction of cAMP-responsive element-binding protein activation induced by scopolamine in the hippocampus. Taken together, the results provide experimental evidence that $A.$ $bidentata$ might be a useful agent against a deficit of learning and memory caused by Alzheimer's disease and aging.

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