지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제11권 제3호
- 발행연도
- 2011.1
- 수록면
- 153 - 160 (8page)
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초록· 키워드
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The present work was aimed to assess the effect of ammonium glycyrrhizinate, $AG$ (50, 100, and 150 mg/kg, i.p.) on haloperidol induced catalepsy in mice; reserpine induced orofacial dyskinesia in rats; and reserpine antagonism in mice. Additionally the effect of $AG$ on lipid peroxidation (LP) in cataleptic mice brain and monoamine oxidase-B (MAO-B) levels in normal mice brain was assessed. Administration of $AG$ 100 and 150 mg/kg showed significant reduction in the duration of cataleptic behavior at 60 to 180 min and dose dependent decrease in LP induced by haloperidol. $AG$ showed significant decrease in frequency of vacuous chewing movements at 150 mg/kg and frequency of tongue protrusion at 100 and 150 mg/kg in reserpine induced orofacial dyskinesia test. $AG$ showed significant increase in frequency of horizontal movement and rearing behavior at 150 mg/kg and increase in grooming behavior at 100 and 150 mg/kg in reserpine antagonism test. $AG$ showed dose dependent inhibition of MAO-B in the normal mice brain. These results suggested that $AG$ prevented the haloperidol- and reserpine- induced neurobehavioral alterations possibly by acting as free radical scavenger or inhibiting MAO-B thereby increasing dopaminergic transmition consequently decreasing dopamine metabolites and ultimately preventing the generation of free radicals.
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