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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Kyu-Yeob (Department of Pharmacology, Oriental Medical Science Center, College of Oriental Medicine, Kyung Hee University) Park, Chan-Won (Department of Biological Science, College of Natural Science, Biochip Research Center, Hoseo University) Kim, Hyung-Min (Department of Pharmacology, Oriental Medical Science Center, College of Oriental Medicine, Kyung Hee University) Kang, In-Cheol (Department of Biological Science, College of Natural Science, Biochip Research Center, Hoseo University) Jeong, Hyun-Ja (Department of Biological Science, College of Natural Science, Biochip Research Center, Hoseo University)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제11권 제1호
발행연도
2011.1
수록면
15 - 23 (9page)

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The present study was to investigate the effects of water extracts of $Acanthopanax$ $divaricatus$ $var.$ $albeofructus$ stem extract (ADE) on an exacerbated immune function through utilization of a protein-energy malnutrition (PEM) diet. ADE has been used in Korea as a tonic and sedative agents as well as a drug with ginseng like activities. However, there is no pronouncing about the immune system on the PEM feeding mice. The immobility time were significantly decreased in the ADE-administrated group as compared to the control group on the forced swimming test ($P$ <0.05). The level of aspartate aminotransferase and lactate dehydrogenase in blood was significantly reduced in the ADE-administrated group ($P$ <0.05). ADE also significantly decreased production of interferon- ${\gamma}$ and interleukin (IL)-4 but not IL-2 in splenocytes ($P$ <0.05). We used a manually antibody microarray to carry out the signaling protein microarray analysis. Unfortunately, we did not find change of protein expression. These results suggest that ADE have the anti-fatigue effect and the immune regulation effect.

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