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논문 기본 정보

자료유형
학술저널
저자정보
정영필 (한국한의학연구원 한의신약연구그룹) 임남희 (한국한의학연구원 한의신약연구그룹) 김애영 (한국한의학연구원 한의신약연구그룹) 황윤환 (한국한의학연구원 한의신약연구그룹) 박화용 (한국한의학연구원 한의신약연구그룹) 마진열 (한국한의학연구원 한의신약연구그룹)
저널정보
대한본초학회 대한본초학회지(본초분과학회지) 대한본초학회지 제28권 제2호
발행연도
2013.1
수록면
61 - 65 (5page)

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Objectives : Samchulgeonbi-tang (shenzhujianpi-tang) has been prescribed as one of traditional herbal medicine for treatment of stomach diseases since ancient time in Korea. Samchulgeonbi-tang extract was fermented by Lactobacillus spp. for improving the effect. However, the toxicity and safety of fermented Samchulgeonbi-tang (FS) extract were not confirmed. Therefore, this study was performed to evaluate the acute toxicity and safety of FS extract. Methods : To evaluate the acute toxicity and safety of FS extract, several doses of FS extract, 0, 500, 1000 and 2000 mg/kg, were orally administered to 20 male and 20 female ICR mice, respectively. After treatment with FS extract, we observed mortality, general toxicity, behavior and change of body weight for the 14 days. After 14 days of oral administration, all mice were sacrificed and hematological parameters were analyzed from blood serum. Results : In present study, the toxic signs such as mortality or abnormal behaviors by FS extract were not observed. There are no significant differences between FS-treated group and control group in body weight, organ weights, and hematological parameters. Conclusions : The remarkable adverse effects by FS extract were not observed in ICR mice. Also, any death was not occurred at all treated FS doses, 500, 1000 and 2000 mg/kg. Therefore, the approximate lethal dose (ALD) of FS extract may be more than 2000 mg/kg.

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