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논문 기본 정보

자료유형
학술저널
저자정보
Jena, Prabhat Kumar (Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Berhampur University) Dinda, Subas Chandra (Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Berhampur University) Ellaiah, P. (Department of Pharmaceutical Technology, Jeypore College of Pharmacy)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제12권 제2호
발행연도
2012.1
수록면
123 - 127 (5page)

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The present study was carried out to investigate the anti-pyretic and anticonvulsant activity of petroleum ether, ethyl acetate, n-butanol and ethanol extracts of Smilax zeylanica Linn, leaves using experimental animal models. The extracts were screened for alkaloids, steroids, proteins, flavanoids, saponins, mucilage, carbohydrates, tannins, fats and oils. Anti-pyretic activity was evaluated using the brewer's yeast-induced pyrexia in rats. The extracts in dose levels of 200 mg/kg orally were used for anti-pyretic studies. The petroleum ether extracts of leaves of Smilax zeylanica Linn produced significant (P<0.01) anti-pyretic activity. Anticonvulsant activity of above extracts was evaluated by using strychnine induced tonic convulsion of Swiss albino mice. All extracts were able to reduce convulsion in mice. The Ethyl acetate extracts of Smilax zeylanica was found to have good anticonvulsant activity in comparison to other extracts which was verified as statistically significant by using one way ANOVA at 1% level of significance $^*$shows P value<0.01.

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