지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The aim of the study was to investigate the efficacy of Boiogito for obesity. We examined the efficacy of Boiogito for obese patients and we expected the reaction of Boiogito would vary according to the single nucleotide polymorphism(SNPs). Methods: 111 subjects(body mass index${\geq}25m/kg^2$) were recruited and randomized to receive Boiogito(n=55) or Placebo(n=56) for 8weeks. Anthropometric factors, serum lipid profile, glucose, blood pressure(BP), pulse rate, resting metabolic rate and Korean version of obesity-related quality of life(KOQOL) scale measured at baseline and 8weeks. SNPs(${\beta}3$-adrenergic receptor(ADRB3), G protein ${\beta}3$(GNB3), peroxisome proliferator activated receptor gamma 2 gene(PPAR-${\gamma}2$), uncoupling protein(UCP2)) were conducted at baseline. Adverse reactions and safety outcome variables were also checked during trials. Results: Both groups showed significant improvement on obesity after treatment. Boiogito group decreased triglyceride than did control group and improved KOQOL. Boiogito showed a significant higher efficacy in C/T and T/T genotype of GNB3 gene / in Trp64 and Arg64 genotype of ADRB3 gene / in D/D genotype of UCP2 gene / in Pro/Pro genotype of PPAR-${\gamma}$ gene. Conclusions: Boiogito promoted obesity indexes without severe adverse reactions and proved its safety. Pharmacogenetical studies of Boiogito on obesity could be a effective method for the individualized treatment and prevention of obesity.
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참고문헌 (33)
참고문헌 신청
Koeppen-Schomerus G / 2001 / A genetic analysis of weight and overweight in 4-year-old twin pairs / Int J Obes Relat Metab Disord 25(6):838~844
Yang W / 2007 / Genetic epidemiology of obesity / Epidemiol Rev 29:49~61
SH, Beck / 2009 / Obesity related gene variations: PPAR-Υ, UCP, β3AR, calpain 10 / Kor J Obes 13(4):34
Jose, A. M. / 2008 / The PPAR trio: Regulators of myocardial energy metabolism in health and disease / J. Molecular and Cellular Cardio 44:968~975
Hsiao DJ / 2009 / Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene / Pharmacogenet Genomics 19(9):730~733
Yang W / 2007 / Genetic epidemiology of obesity / Epidemiol Rev 29:49~61
SH, Beck / 2009 / Obesity related gene variations: PPAR-Υ, UCP, β3AR, calpain 10 / Kor J Obes 13(4):34
Jose, A. M. / 2008 / The PPAR trio: Regulators of myocardial energy metabolism in health and disease / J. Molecular and Cellular Cardio 44:968~975
Hsiao DJ / 2009 / Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene / Pharmacogenet Genomics 19(9):730~733
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