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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: This study was to evaluate the effect of Palmijihwang-whan (PMJHW) aqueous extract in the regulation of hypothyroidism related reproductive organ damages in propylthiouracil (PTU)-induced rat model. Methods: PMJHW aqueous extract (yield=17.90%) were administered, once a day for 42 days from 2 weeks before start of PTU treatment as oral doses of 500, 250, and 125 mg/kg (body weight), and hypothyroidism was induced by daily subcutaneous treatment of PTU 10 mg/kg for 28 days. Results: PTU-induced hypothyroidism and related male reproductive organ damages-atrophic changes of testis, epididymis and prostate, were favorably and dose-dependently inhibited by treatment of PMJHW 500, 250, and 125 mg/kg. They also effectively regulated the PTU-induced abnormal antioxidant defense system changes in the testis. Although levothyroxine also favorably inhibited PTU-induced hypothyroidism, it deteriorated the hypothyroidism related male reproductive organ damages through testicular oxidative damages. The results suggest that oral administration of 125, 250, and 500 mg/kg of PMJHW has favorable effects on the hypothyroidism and related reproductive organ damages through augmentation of antioxidant defense system in the testis. Conclusions: This study suggest that PMJHW may be help to ameliorate the hypothyroidism and related organ damages in clinics.
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참고문헌 (33)
참고문헌 신청
Doo J / 1993 / DongEuNephrology / Oriental Medicine Research Office :1059~1065
Kim M / 2008 / Treatment on thyroid diseases in Hyungsang medicine / J Hyungsang Orient Med Clin 9(1):351~392
Lee J / 1994 / Thyroid diseases for clinicians / Ryumoongak :125~126
Subudhi U / 2009 / Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitecture in hypothyroid rats / Life Sci 84(11):372~379
Choudhury S / 2003 / Experimentally induced hypo- and hyper-thyroidism influence on the antioxidant defence system in adult rat testis / Andrologia 35(3):131~140
Kim M / 2008 / Treatment on thyroid diseases in Hyungsang medicine / J Hyungsang Orient Med Clin 9(1):351~392
Lee J / 1994 / Thyroid diseases for clinicians / Ryumoongak :125~126
Subudhi U / 2009 / Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitecture in hypothyroid rats / Life Sci 84(11):372~379
Choudhury S / 2003 / Experimentally induced hypo- and hyper-thyroidism influence on the antioxidant defence system in adult rat testis / Andrologia 35(3):131~140
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