지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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PURPOSE: This study examined the effects of treadmill exercise of diverse intensities on the expression of IL-$1{\beta}$ (interleukine-$1{\beta}$) in the spinal cord in osteoarthritis rats. METHODS: The authors applied treadmill exercise of diverse intensity for 4 weeks to Sprague-Dawley rats to which intra-articular injection of monosodium iodoacetate(MIA, $3mg/50{\mu}l$, diluted in saline) was applied in the right knee joint to induce osteoarthritis. The four-week exercise was not applied to the control group(CG, n=15), while exercise of applicable intensity was applied to the low-intensity exercise group(LEG, n=15), moderate-intensity exercise group (MEG, n=15), and high-intensity exercise group(HEG, n=15) for four weeks. Observations were made of expression of IL-$1{\beta}$ in the spinal cord in osteoarthritis rats using western blot analysis. RESULTS: There were significant differences(p<.05) in the comparison of expression of IL-$1{\beta}$ in the spinal cord between the four groups involved. And the LEG and MEG had reduced expression of IL-$1{\beta}$ significantly than the CG(p<.05); in particular, the MEG showed the lowest expression. On the other hand, the HEG had more elevated expression of IL-$1{\beta}$ significantly than the CG(p<.05). CONCLUSION: As a result, factors that induce neuropathic pain such as IL-$1{\beta}$ are reduced; thus, the recovery of damaged neurons is improved and neuropathic pain is reduced. Further, when prescribing exercise to treat osteoarthritis patients, exercise of moderate intensity suitable for patients' physical conditions, rather than high intensity, maximizes the effects of this therapy.
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참고문헌 (29)
참고문헌 신청
Baek KY / 2008 / The effect of different exercise intensity on the blood pressure and inflammatory markers change in pre-hypertension leveled male
Byun KS / 2010 / Effect of exercise intensity on GLUT-4 expression of skeletal muscle and insulin resistance in type 1 diabetic rats
최정훈 / 2009 / Colocalization of Calcitonin Gene-Related Peptide and Substance P in the Purkinje Cells in the Colchicine-Treated Gerbil / Laboratory Animal Research 25(1):15~18
Choi JK / 2010 / The Effects of high intensity exercise and DA-9601 administration on antioxidant enzyme activities and TNF-α, IL-1β mRNA expression in rats
Constandil L / 2009 / Effect of interleukin-1β on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function / Arthritis Res Ther 11(4):105~113
Byun KS / 2010 / Effect of exercise intensity on GLUT-4 expression of skeletal muscle and insulin resistance in type 1 diabetic rats
최정훈 / 2009 / Colocalization of Calcitonin Gene-Related Peptide and Substance P in the Purkinje Cells in the Colchicine-Treated Gerbil / Laboratory Animal Research 25(1):15~18
Choi JK / 2010 / The Effects of high intensity exercise and DA-9601 administration on antioxidant enzyme activities and TNF-α, IL-1β mRNA expression in rats
Constandil L / 2009 / Effect of interleukin-1β on spinal cord nociceptive transmission of normal and monoarthritic rats after disruption of glial function / Arthritis Res Ther 11(4):105~113
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