지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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PURPOSE: The purpose of this study was to compare the effect of current density on penetration depth, tissue concentration and transdermal transport of methylene blue(MB) by iontophoretic transdermal delivery. METHODS: Twenty-four male Sprague-Dawley rats were randomly divided into 1 mA($0.11mA/cm^2$), 2 mA($0.22mA/cm^2$), 4 mA($0.44mA/cm^2$), and 8 mA($0.89mA/cm^2$) groups. These rats were exposed to anodic iontophoresis of 1% MB using a direct current for 15 minutes. The penetration depth were measured using light microscopy from cryosections of skin tissue. The tissue concentration and transdermal transport were measured using biochemical analysis from target skin tissues. The data were analyzed with one-way analysis of variance. RESULTS: The significant differences in the penetration depth, tissue concentration and transdermal transport were detected among the groups(p<.001). Post hoc comparisons of the penetration depth, tissue concentration and transdermal transport of he 2 mA, 4 mA, and 8 mA iontophoresis groups were greater than in the 1 mA iontophoresis group(p<.05). There was no significant difference, however, among 2 mA, 4 mA, and 8 mA iontophoresis group. CONCLUSION: There was no difference in the efficiency of iontophoresis from 2 mA($0.22mA/cm^2$) to 8 mA($0.89mA/cm^2$). Higher current density can cause skin injury and discomfort sensation. In general, $0.5mA/cm^2$ is proposed to be the maximum iontophoretic current which should be used on human. The appropriate current amplitude should be selected by considering the safety current density and the depth of the target tissue.
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참고문헌 (29)
참고문헌 신청
Barry BW / 2002 / Drug delivery routes in skin: a novel approach / Adv Drug Deliv Rev 54(1):S31~S40
Barry BW / 2001 / Novel mechanisms and devices to enable successful transdermal drug delivery / Eur J Pharm Sci 14(2):101~114
Benson HA / 2005 / Transdermal drug delivery: penetration enhancement techniques / Curr Drug Deliv 2(1):23~33
Brown MB / 2006 / Dermal and transdermal drug delivery systems: current and future prospects / Drug Deliv 13(3):175~187
Cázares-Delgadillo J / 2010 / Transdermal iontophoresis of dexamethasone sodium phosphate in vitro and in vivo: effect of experimental parameters and skin type on drug stability and transport kinetics / Eur J Pharm Biopharm 75(2):173~178
Barry BW / 2001 / Novel mechanisms and devices to enable successful transdermal drug delivery / Eur J Pharm Sci 14(2):101~114
Benson HA / 2005 / Transdermal drug delivery: penetration enhancement techniques / Curr Drug Deliv 2(1):23~33
Brown MB / 2006 / Dermal and transdermal drug delivery systems: current and future prospects / Drug Deliv 13(3):175~187
Cázares-Delgadillo J / 2010 / Transdermal iontophoresis of dexamethasone sodium phosphate in vitro and in vivo: effect of experimental parameters and skin type on drug stability and transport kinetics / Eur J Pharm Biopharm 75(2):173~178
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