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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives Previous studies suggest that the cannabinoid receptor 1 (CNR1) gene could be an important candidate gene for schizophrenia. According to linkage studies, this gene is located on chromosome 6q14-q15, which is known to harbor the schizophrenia susceptibility locus (locus 5, SCZ5, OMIM 803175). The pharmacological agent delta-9-tetrahydrocannabinol (${\Delta}$-9-THC) seems to elicit the symptoms of schizophrenia. The association between CNR1 polymorphisms and schizophrenia is actively being investigated, and some studies have linked the AAT-trinucleotide repeats in CNR1 to the onset of schizophrenia. In this study, we have investigated the association between the AAT-trinucleotide repeats in CNR1 and schizophrenia by studying schizophrenia patients and healthy individuals from Korea. Methods DNA was extracted from the blood samples of 394 control subjects and 337 patients diagnosed with schizophrenia (as per the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria). After polymerase chain reaction amplification, a logistic regression analysis, with age and gender as the covariates, was performed to study the variations in the AAT-repeat polymorphisms between the two groups. Results In total, 8 types of trinucleotide repeats were identified, each containing 7, 8, 10, 11, 12, 13, 14, and 15 repeats, respectively. $(AAT)_{13}$ allele was most frequently observed, with a frequency of 33.6% and 31.6% in the patient and control groups, respectively. The frequency of the other repeat alleles in the patient group (in the decreasing order) was as follows : $(AAT)_{13}$ 33.6%, $(AAT)_{14}$ 21.6%, $(AAT)_{12}$ 18.5%, and $(AAT)_{7}$ 11.1%. The frequency of the repeat alleles in the control group (in the decreasing order) was as follows : $(AAT)_{13}$ 31.6%, $(AAT)_{14}$ 24.5%, $(AAT)_{12}$ 17.2%, and $(AAT)_{7}$ 11.6%. However, there were no significant differences in the AAT-repeat polymorphisms of the CNR1 gene between the patient group and the control group. Conclusions Although our study revealed no significant association of the AAT-repeat polymorphism of the CNR1 gene with schizophrenia, it will serve as a good reference for future studies designed to examine the cannabinoid hypothesis of schizophrenia.
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참고문헌 (25)
참고문헌 신청
Karayiorgou M / 1997 / A turning point in schizophrenia genetics / Neuron 19:967~979
Ujike H / 2004 / New perspectives in the studies on endocannabinoid and cannabis : cannabinoid receptors and schizophrenia / J Pharmacol Sci 96:376~381
Sewell RA / 2009 / Cannabinoids and psychosis / Int Rev Psychiatry 21:152~162
Martínez-Gras I / 2006 / (AAT)n repeat in the cannabinoid receptor gene, CNR1 : association with schizophrenia in a Spanish population / Eur Arch Psychiatry Clin Neurosci 256:437~441
Liskow B / 1970 / Marihuana deterioration / JAMA 214:1709
Ujike H / 2004 / New perspectives in the studies on endocannabinoid and cannabis : cannabinoid receptors and schizophrenia / J Pharmacol Sci 96:376~381
Sewell RA / 2009 / Cannabinoids and psychosis / Int Rev Psychiatry 21:152~162
Martínez-Gras I / 2006 / (AAT)n repeat in the cannabinoid receptor gene, CNR1 : association with schizophrenia in a Spanish population / Eur Arch Psychiatry Clin Neurosci 256:437~441
Liskow B / 1970 / Marihuana deterioration / JAMA 214:1709
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