지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Glutamate receptors are important components of synaptic transmission in the nervous system. Especially, ${\alpha}$-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate most abundant excitatory synaptic transmission in the brain. There is elaborate mechanism of regulation of AMPA receptors including protein synthesis/degradation, intracellular trafficking, exocytosis/endocytosis and protein modification. In recent studies, it is revealed that functional dysregulation of AMPA receptors are related to major psychiatric disorders. In this review, we describe the structure and function of AMPA receptors in the synapse. We will introduce three steps of mechanism involving trafficking of AMPA receptors to neuronal membrane, lateral diffusion into synapses and synaptic retention by membrane proteins and postsynaptic scaffold proteins. Lastly, we will describe recent studies showing that regulation of AMPA receptors is important pathophysiological mechanism in psychiatric disorders.
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참고문헌 (52)
참고문헌 신청
Brose N / 2010 / Synaptopathy: dysfunction of synaptic function? / Biochem Soc Trans 38:443~444
Arendt T / 2009 / Synaptic degeneration in Alzheimer’s disease / Acta Neuropathol 118:167~179
Hall J / 2009 / Associative learning and the genetics of schizophrenia / Trends Neurosci 32:359~365
Betancur C / 2009 / The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders / Trends Neurosci 32:402~412
Mayer ML / 1987 / The physiology of excitatory amino acids in the vertebrate central nervous system / Prog Neurobiol 28:197~276
Arendt T / 2009 / Synaptic degeneration in Alzheimer’s disease / Acta Neuropathol 118:167~179
Hall J / 2009 / Associative learning and the genetics of schizophrenia / Trends Neurosci 32:359~365
Betancur C / 2009 / The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders / Trends Neurosci 32:402~412
Mayer ML / 1987 / The physiology of excitatory amino acids in the vertebrate central nervous system / Prog Neurobiol 28:197~276
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