지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objectives Alteration of epigenetic effects of testosterone during early development was suggested as an ancillary mechanism for the genesis of schizophrenia. EEG coherence was thought to be a marker for cerebral laterality of which important determinant was testosterone during early development. We studied sex-related differences of EEG coherences between patients with schizophrenia and controls to examine the sex effects in the genesis of schizophrenia. Methods EEG was recorded in 35 patients with schizophrenia and 46 healthy controls in the eyes closed resting state. Pair-wise EEG coherences were calculated over delta, theta, alpha, beta and gamma frequency bands. To examine the differences of EEG coherence according to sex in each group, ANCOVA was performed using Statistical Analysis system (SAS, Ver 9.3) and R (Ver 2.15.2). Results Healthy control males showed more increased right intrahemispheric coherences than healthy control females in delta, theta, alpha and beta frequency bands. In patients with schizophrenia, this male dominant pattern in right intrahemispheric coherences was attenuated especially in alpha and beta bands. Healthy control females showed more increased interhemispheric coherences than healthy control males in delta, theta, beta and gamma frequency bands. In patients with schizophrenia, these female dominant patterns in interhemispheric coherences were attenuated especially in delta, theta, and beta bands, which were commonly observed in frontal to central areas. Conclusion Sex differences in resting EEG coherences were attenuated in schizophrenia patients. These results imply that sex-related aberrant cerebral lateralization might exist in patients with schizophrenia, which are partly due to sex hormones via epigenetic mechanisms.
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참고문헌 (77)
참고문헌 신청
Maccoby EM / 1974 / The psychology of sex differences / Standford University Press :17~276
Geschwind N / 1985 / Cerebral lateralization. Biological mechanisms, associations, and pathology: III. A hypothesis and a program for research / Arch Neurol 42:634~654
Bianki VL / 2000 / Sex Differences in Lateralization in the Animal Brain / Harwood Academic Publishers :1~18
Wada Y / 1996 / Interhemispheric EEG coherence during photic stimulation: sex differences in normal young adults / Int J Psychophysiol 22:45~51
Beaumont JG / 1978 / Asymmetry in EEG alpha coherence and power: effects of task and sex / Electroencephalogr Clin Neurophysiol 45:393~401
Geschwind N / 1985 / Cerebral lateralization. Biological mechanisms, associations, and pathology: III. A hypothesis and a program for research / Arch Neurol 42:634~654
Bianki VL / 2000 / Sex Differences in Lateralization in the Animal Brain / Harwood Academic Publishers :1~18
Wada Y / 1996 / Interhemispheric EEG coherence during photic stimulation: sex differences in normal young adults / Int J Psychophysiol 22:45~51
Beaumont JG / 1978 / Asymmetry in EEG alpha coherence and power: effects of task and sex / Electroencephalogr Clin Neurophysiol 45:393~401
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