지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives To investigate the pattern of subclinical hypothyroidism (SCH) in patients with bipolar disorders managed by lithium or valproic acid. Methods The study participants were 106 patients with DSM-IV bipolar disorders receiving planned maintenance treatment at the Mood Disorders Clinic of Seoul National University Bundang Hospital (aged between 17 and 64, mean duration of follow-up = 875.65 days). Using the bipolar disorder registry, thyroid function data were analyzed to assess the frequency of and the risk factors for SCH in patients managed by lithium (n = 64) or valproic acid (n = 42) for more than 5 months. Results Overall frequencies of SCH were 20.3% (13/64) in the lithium group, 14.3% (6/42) in the valproic acid group, and between the two groups there is no difference (p = 0.43). No differences were observed in the potential risk factors for SCH between the two groups including age, sex, subtype of bipolar disorder, baseline TSH, and concomitant antipsychotic use. In cases with SCH, thyroid-stimulating hormone (TSH) showed a tendency to increase at 3 month after the initiation of lithium or valproic acid. A gradual increase in the number of patients showing SCH was found within the first 3 years of medication. Conclusions With regular monitoring and careful assessment, there was no difference in the risk of SCH between lithium and valproic acid maintenance. The risk of mood stabilizer-associated SCH may gradually increase within 3 years following the commencement of medication, thereby mandating close monitoring for the first 3 years of treatment. Further studies with large sample size would be needed to confirm these findings.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Bauer M / 2008 / The thyroid-brain interaction in thyroid disorders and mood disorders / J Neuroendocrinol 20:1101~1114
Bunevicius R / 2006 / Psychiatric manifestations of Graves’ hyperthyroidism: pathophysiology and treatment options / CNS Drugs 20:897~909
Howland RH / 1993 / Thyroid dysfunction in refractory depression: implications for pathophysiology and treatment / J Clin Psychiatry 54:47~54
Müller-Oerlinghausen B / 2002 / Bipolar disorder / Lancet 359:241~247
Kupka RW / 2003 / Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studies / J Clin Psychiatry 64:1483~1494
Bunevicius R / 2006 / Psychiatric manifestations of Graves’ hyperthyroidism: pathophysiology and treatment options / CNS Drugs 20:897~909
Howland RH / 1993 / Thyroid dysfunction in refractory depression: implications for pathophysiology and treatment / J Clin Psychiatry 54:47~54
Müller-Oerlinghausen B / 2002 / Bipolar disorder / Lancet 359:241~247
Kupka RW / 2003 / Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studies / J Clin Psychiatry 64:1483~1494
이 논문의 저자 정보
최근 본 자료
댓글(0)
0