지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Variety of biomarkers that are related to the Alzheimer's disease and its diagnosis and progress have been found. However, research lacks in predicting the reaction of the treatment. In addition, there is no definite treatment reaction to the disease but rather it is varied. The purpose of this review article is to study the research of the biomarkers that are able to predict the treatment reaction. There was a research that illustrated a relationship between plasma amyloid ${\beta}$ peptide, cerebrospinal fluid tau, neuroanatomical biomarkers and acetylcholinesterase inhibitors. Polymorphisms in genes of the cholinergic markers AChE, BuChE, ChAT and PON-1 were found to be associated with better clinical response to acetylcholinesterase inhibitors. Many pharmacogenetic studies have been conducted to evaluate the impact of the lipoprotein apolipoprotein E (APOE) genotype on treatment response to acetylcholinesterase inhibitor. However, there is no significant influence of the APOE genotypes on treatment response. Further research is needed to find other predictors of treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Miller BL / 2009 / The behavioral neurology of dementia / Cambridge University Press
Jack CR Jr / 2010 / Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade / Lancet Neurol 9:119~128
Albert MS / 2011 / The diagnosis of mild cognitive impairment due to Alzheimer’s disease : recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease / Alzheimers Dement 7:270~279
Sobow T / 2007 / Plasma Abeta levels as predictors of response to rivastigmine treatment in Alzheimer’s disease / Acta Neurobiol Exp(Wars) 67:131~139
Wallin AK / 2009 / Can CSF biomarkers or pre-treatment progression rate predict response to cholinesterase inhibitor treatment in Alzheimer’s disease? / Int J Geriatr Psychiatry 24:638~647
Jack CR Jr / 2010 / Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade / Lancet Neurol 9:119~128
Albert MS / 2011 / The diagnosis of mild cognitive impairment due to Alzheimer’s disease : recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease / Alzheimers Dement 7:270~279
Sobow T / 2007 / Plasma Abeta levels as predictors of response to rivastigmine treatment in Alzheimer’s disease / Acta Neurobiol Exp(Wars) 67:131~139
Wallin AK / 2009 / Can CSF biomarkers or pre-treatment progression rate predict response to cholinesterase inhibitor treatment in Alzheimer’s disease? / Int J Geriatr Psychiatry 24:638~647
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