지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives It was the aim to examine the association of the thyroid-related hormones with cognitive function, depression, and subjective memory impairment in community-dwelling elders with questionable dementia. Methods The sample consisted of 399 community residents with 'questionable dementia' aged 60 or over in whom serum thyroid-related hormones [thyroid stimulating hormone (TSH) and thyroxine] had been assayed. Cognitive impairment was defined using the Korean version of the Consortium Establish a Registry for Alzheimer's Disease. Depression was diagnosed using the Korean version of Geriatric Depression Scale and subjective memory complaint (SMC) was checked using the subjective memory complaints questionnaire (SMCQ). Age, gender, education, and the presence of apolipoprotein E {\varepsilon}4 were included as covariates. Results There was a significant positive association between verbal fluency test (VFT) score and serum TSH levels (p = 0.01). There was a significant negative association between SMCQ total score and word list memory test (WLMT)(p = 0.002) or word list recall test (WLRT) score (p = 0.013). Conclusions Lower serum TSH levels were associated with semantic memory (VFT), and we found that SMC was associated with episodic memory (WLMT and WLRT) in this sample.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Reiman EM / 2004 / Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia / Proc Natl Acad Sci U S A 101:284~289
Freemantle E / 2006 / Omega-3 fatty acids, energy substrates, and brain function during aging / Prostaglandins Leukot Essent Fatty Acids 75:213~220
김재민 / 2010 / Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population / PSYCHIATRY INVESTIGATION 7(4):264~269
de Jongh RT / 2011 / Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals / Eur J Endocrinol 165:545~554
Bégin ME / 2008 / Thyroid function and cognition during aging / Curr Gerontol Geriatr Res :474868
Freemantle E / 2006 / Omega-3 fatty acids, energy substrates, and brain function during aging / Prostaglandins Leukot Essent Fatty Acids 75:213~220
김재민 / 2010 / Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population / PSYCHIATRY INVESTIGATION 7(4):264~269
de Jongh RT / 2011 / Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals / Eur J Endocrinol 165:545~554
Bégin ME / 2008 / Thyroid function and cognition during aging / Curr Gerontol Geriatr Res :474868
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