지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives The aim of this study is to evaluate the association between rs6280 and rs905568 genetic polymorphism of DRD3 gene and the treatment response of amisulpride. Methods After six weeks treatment of amisulpride, 125 schizophrenia patients were interviewed based on the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-Severity (CGI-S). The genotyping for rs6280 and rs905568 was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay. Results There was no significant difference in the frequency of genotype and allele of rs6280 between the responders and non-responders based on the total, positive, and general score of PANSS and CGI-S score. However, there was a significant association between this SNP and treatment response in the negative score of PANSS (${\chi}^2=5.23$, p = 0.022). There was no significant association between rs905568 and the response in positive, negative, general, and total PANSS score and CGI-S score. Conclusions This is the first positive association study between DRD3 gene and the treatment response of negative symptoms to amisulpride in Korean schizophrenia patients. A larger scale research on more SNP of the DRD3 gene will make a progress in the study of pharmacogenetics on the treatment response of the amisulpride.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
MÖller HJ / 1997 / Improvement of acute exacerbations of schizophrenia with amisulpride: a comparison with haloperidol. PROD-ASLP Study Group / Psychopharmacology (Berl) 132:396~401
Puech A / 1998 / Amisulpride, and atypical antipsychotic, in the treatment of acute episodes of schizophrenia: a dose-ranging study vs. haloperidol. The Amisulpride Study Group / Acta Psychiatr Scand 98:65~72
Mortimer A / 2004 / SOLIANOL Sudy Group. A double-blind, randomized comparative trial of amisulpride versus olanzapine for 6 months in the treatment of schizophrenia / Int Clin Psychopharmacol 19:63~69
Peuskens J / 1999 / Amisul- pride vs. risperidone in the treatment of acute exacerbations of schizophrenia. Amisulpride study group / Psychiatry Res 88:107~117
Kahn RS / 2008 / Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial / Lancet 371:1085~1097
Puech A / 1998 / Amisulpride, and atypical antipsychotic, in the treatment of acute episodes of schizophrenia: a dose-ranging study vs. haloperidol. The Amisulpride Study Group / Acta Psychiatr Scand 98:65~72
Mortimer A / 2004 / SOLIANOL Sudy Group. A double-blind, randomized comparative trial of amisulpride versus olanzapine for 6 months in the treatment of schizophrenia / Int Clin Psychopharmacol 19:63~69
Peuskens J / 1999 / Amisul- pride vs. risperidone in the treatment of acute exacerbations of schizophrenia. Amisulpride study group / Psychiatry Res 88:107~117
Kahn RS / 2008 / Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial / Lancet 371:1085~1097
이 논문의 저자 정보
최근 본 자료
댓글(0)
0