지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives Non-major depression with fewer symptoms than required for a Diagnostic and Statistical Manual of Mental Disorders-4th edition diagnosis of major depressive disorder (MDD) has consistently been found to be associated with functional impairment. In this study, we aim to estimate the cognitive impairment and the quality of life in elderly patients with subsyndromal depression (SSD) compared with non-depressive elderly (NDE). Methods The Korean version of Mini International Neuropsychiatric Interview was administered to 194 outpatients with depression and 108 normal controls. SSD is defined as having five or more current depressive symptoms with core depressive symptoms (depressive mood or loss of interest or pleasure) during more than half a day and more than seven days over two weeks. Depression was evaluated by the Korean form of Geriatric Depression Scale of a 15-item short version. Global cognition was assessed by Mini-Mental State Examination in the Korean version of CERAD assessment packet (MMSE-KC). Subjective cognitive impairment was assessed by the Subjective Memory Complaint Questionnaire. Quality of life was evaluated by the Korean Version of Short-Form 36-Item Health Survey. Results The mean score of the MMSE-KC in the SSD group was lower than that in the NDE group with adjustment for age, gender, and education [F = 4.270, p = 0.04, analysis of covariance (ANCOVA)]. If we defined those having Z-score of MMSE-KC < -1.5 as a high risk group of cognitive impairment, the odds ratio for the high risk group of cognitive impairment was 1.86 [95% confidence intervals (CI) 1.04-3.34] in SSD and 7.57 (95% CI 3.50-16.40) in MDD compared to NDE. The scores of physical component summary (F = 9.274, p = 0.003, ANCOVA) and mental component summary (F = 53.166, p < 0.001, ANCOVA) in the SSD group were lower than those in the NDE group with adjustment for age, gender, and education. Conclusions The subjects with SSD, as well as those with MDD, showed impairment of global cognition and also experienced low quality of life in both physical and mental aspects, compared to the NDE group.
목차
등록된 정보가 없습니다.
참고문헌 (53)
참고문헌 신청
Park JH / 2010 / Prevalence of major depressive disorder and minor depressive disorder in an elderly Korean population: results from the Korean Longitudinal Study on Health and Aging (KLoSHA) / J Affect Disord 125:234~240
American Psychiatric Association / 2000 / Diagnostic and statistical manual of mental disorders: DSM-IV-TR / American Psychiatric Association
박준혁 / 2011 / 아증후군적 우울증 / 생물정신의학 18(4):210~216
Jeong HG / 2013 / Role of severity and gender in the association between late-life depression and all-cause mortality / Int Psychogeriatr 25:677~684
Pietrzak RH / 2012 / Subsyndromal depression in the United States: prevalence, course, and risk for incident psychiatric outcomes / Psychol Med :1~14
American Psychiatric Association / 2000 / Diagnostic and statistical manual of mental disorders: DSM-IV-TR / American Psychiatric Association
박준혁 / 2011 / 아증후군적 우울증 / 생물정신의학 18(4):210~216
Jeong HG / 2013 / Role of severity and gender in the association between late-life depression and all-cause mortality / Int Psychogeriatr 25:677~684
Pietrzak RH / 2012 / Subsyndromal depression in the United States: prevalence, course, and risk for incident psychiatric outcomes / Psychol Med :1~14
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