지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives Mechanisms of clinical synergistic effects, induced by co-treatments of lithium and valproate, are unclear. Extracellular signal-regulated kinase (ERK) has been suggested to play important roles in mechanisms of the action of mood stabilizers. In this study, effects of co-treatments of lithium and valproate on the ERK1/2 signal pathway and its down-stream transcription factors, ELK1 and C-FOS, were investigated in vitro. Methods PC12 cells, human pheochromocytoma cells, were treated with lithium chloride (30 mM), valproate (1 mM) or lithium chloride + valproate. The phosphorylation of ERK1/2 was analyzed with immunoblot analysis. Transcriptional activities of ELK1 and C-FOS were analyzed with reporter gene assay. Results Single treatment of lithium and valproate increased the phosphorylation of ERK and transcriptional activities of ELK1 and C-FOS, respectively. Combined treatments of lithium and valproate induced more robust increase in the phosphorylation of ERK1/2 and transcriptional activities of ELK1 and C-FOS, compared to those in response to single treatment of lithium or valproate. Conclusions Co-treatments of lithium and valproate induced synergistic increase in the phosphorylation of ERK1/2 and transcriptional activities of its down-stream transcription factors, ELK1 and C-FOS, compared to effects of single treatment. The findings might suggest potentiating effects of lithium and valproate augmentation treatment strategy.
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참고문헌 (58)
참고문헌 신청
Cipriani A / 2011 / Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis / Lancet 378:1306~1315
Cruz N / 2010 / Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis / Int J Neuropsychopharmacol 13:5~14
Yatham LN / 2013 / Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013 / Bipolar Disord 15:1~44
Goodwin GM / 2009 / Consensus Group of the British Association for Psychopharmacology. Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for Psychopharmacology / J Psychopharmacol 23:346~348
Freeman MP / 1998 / Mood stabilizer combinations: a review of safety and efficacy / Am J Psychiatry 155:12~21
Cruz N / 2010 / Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis / Int J Neuropsychopharmacol 13:5~14
Yatham LN / 2013 / Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013 / Bipolar Disord 15:1~44
Goodwin GM / 2009 / Consensus Group of the British Association for Psychopharmacology. Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for Psychopharmacology / J Psychopharmacol 23:346~348
Freeman MP / 1998 / Mood stabilizer combinations: a review of safety and efficacy / Am J Psychiatry 155:12~21
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