지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives : The purpose of this study is to investigate the relationship between the triallelic serotonin transporter gene and stressful life events to determine their effect on depression with alcohol dependence. Methods : Ninety-five hospitalized patients with alcohol dependence (73 male, 22 female) were enrolled in this study. Thirty-two (33.7%) of the total patients were diagnosed with major depressive disorder and dysthymic disorder by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV. The characteristics of stress were evaluated using the stressful life events scale, and depressive symptoms were assessed using the depression scale (Beck Depression Inventory, BDI). Alcoholism with depression (n = 32) and alcoholism without depression (n = 63) were genotyped for the triallelic serotonin transporter gene ($L_A$ : higher expressing allele, $L_G$/S : lower expressing allele). Results : There was no significant difference in the allele frequency between the depression group and the non-depression group (${\chi}^2$ = 0.345, p = 0.619). $L_G$/S alleles had more comorbid depression in the higher score of stressful life events scale [Mental-Haenszel (MH)-${\chi}^2$ = 4.477, p = 0.034]. But there was no significant difference in the comorbidity according to the scores from the stressful life event scale in the $L_A$ alleles (MH-${\chi}^2$ = 0.741, p = 0.399). In the results, alcohol-dependent individuals with $L_G$/S alleles had more comorbid depression than those with $L_A$ alleles when they had experienced severe stressful life events (MH-odds ratio = 2.699, p = 0.028). Conclusions : These results suggest that there is no direct relationship between triallelic serotonin transporter gene and depression in the alcohol dependent patients. But alcohol dependent individuals with the lower expressing alleles of the serotonin transporter gene were more susceptible to depression than those with the higher expressing alleles in response to stressful life events.
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참고문헌 (31)
참고문헌 신청
Owens MJ / 1994 / Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter / Clin Chem 40:288~295
Heils A / 1996 / Allelic variation of human serotonin transporter gene expression / J Neurochem 66:2621~2624
Lesch KP / 1996 / Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region / Science 274:1527~1531
Lesch KP / 1996 / The role of neurotransporters in excitotoxicity, neuronal cell death, and other neurodegenerative processes / J Mol Med (Berl) 74:365~378
Nakamura M / 2000 / The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants / Mol Psychiatry 5:32~38
Heils A / 1996 / Allelic variation of human serotonin transporter gene expression / J Neurochem 66:2621~2624
Lesch KP / 1996 / Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region / Science 274:1527~1531
Lesch KP / 1996 / The role of neurotransporters in excitotoxicity, neuronal cell death, and other neurodegenerative processes / J Mol Med (Berl) 74:365~378
Nakamura M / 2000 / The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants / Mol Psychiatry 5:32~38
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