지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The placebo effect, a response observed during the placebo arm of a clinical trial, is produced by the psychobiological action of the placebo as well as by other potential contributors to symptom amelioration such as spontaneous improvement, regression to the mean, biases, concurrent treatments, and study design. From a psychological viewpoint, there are many mechanisms that contribute to placebo effects, including expectations, conditioning, learning, and anxiety reduction. Placebo responses are also mediated by opioid and non-opioid mechanisms including dopamine, serotonin, cholecystokinin, and immune mediators. During recent years, a trend towards increased placebo effects in clinical trials of neuropsychiatric drugs has been noted. Indeed, the placebo effects observed in clinical trials constitute an increasing problem and interfere with signal-detection analyses of potential treatments. Several potential factors including protocol/study design and conduct related factors may account for the placebo effect observed in clinical trials. This paper reviews key issues related to this problem and aims to identify potential solutions.
목차
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참고문헌 (69)
참고문헌 신청
Price DD / 2008 / A comprehensive review of the placebo effect: recent advances and current thought / Annu Rev Psychol 59:565~590
Benedetti F / 2011 / The placebo response: how words and rituals change the patient’s brain / Patient Educ Couns 84:413~419
Alphs L / 2012 / Placebo-related effects in clinical trials in schizophrenia: what is driving this phenomenon and what can be done to minimize it? / Int J Neuropsychopharmacol 15:1003~1014
Kemp AS / 2010 / What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it? / Schizophr Bull 36:504~509
Benedetti F / 2009 / Placebo effects: understanding the mechanisms in health and disease / Oxford University Press :38~46
Benedetti F / 2011 / The placebo response: how words and rituals change the patient’s brain / Patient Educ Couns 84:413~419
Alphs L / 2012 / Placebo-related effects in clinical trials in schizophrenia: what is driving this phenomenon and what can be done to minimize it? / Int J Neuropsychopharmacol 15:1003~1014
Kemp AS / 2010 / What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it? / Schizophr Bull 36:504~509
Benedetti F / 2009 / Placebo effects: understanding the mechanisms in health and disease / Oxford University Press :38~46
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