지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Substance addiction is a chronically relapsing disorder that has been characterized by a vicious cycle composed of intoxication, craving/anticipation, withdrawal, and response inhibition/bingeing. Here we summarize the findings from neuroimaging studies in addiction according to these behavioral components and suggest the integrated neurobiological model of drug addiction and related brain correlates. The roles of various prefrontal regions, thalamus, memory circuit, anterior cingulated, and insula were also suggested in addition to those of classical mesolimbic dopaminergic system and its responsivity. Limited studies of behavioral addiction demonstrated a similarity with substance addiction on the neurobiological basis. Based on the current understanding of neurobiology of addiction, further researches on interactions of behavioral components and their brain correlates, behavioral addiction, and therapeutic applications will be desired.
목차
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참고문헌 (97)
참고문헌 신청
Koob GF / 1997 / Drug abuse: hedonic homeostatic dysregulation / Science 278:52~58
Koob GF / 2010 / Neurocircuitry of addiction / Neuropsychopharmacology 35:217~238
Daglish MR / 2003 / Brain imaging studies in human addicts / Eur Neuropsychopharmacol 13:453~458
Blum K / 2000 / Reward deficiency syndrome: a biogenetic model for the di agnosis and treatment of impulsive, addictive, and compulsive behaviors / J Psychoactive Drugs 32:1~112
Goldstein RZ / 2002 / Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex / Am J Psychiatry 159:1642~1652
Koob GF / 2010 / Neurocircuitry of addiction / Neuropsychopharmacology 35:217~238
Daglish MR / 2003 / Brain imaging studies in human addicts / Eur Neuropsychopharmacol 13:453~458
Blum K / 2000 / Reward deficiency syndrome: a biogenetic model for the di agnosis and treatment of impulsive, addictive, and compulsive behaviors / J Psychoactive Drugs 32:1~112
Goldstein RZ / 2002 / Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex / Am J Psychiatry 159:1642~1652
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