지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives This study aimed to identify the differences and the profiles of cognitive deficits in remitted patients with schizophrenia and first-degree relatives of schizophrenic probands. Methods A total of 26 remitted states of schizophrenia patients were included in the study and the same number of unaffected first-degree relatives of schizophrenic probands and healthy controls were matched for age, sex, years of education. Cognitive function of all participants was measured by using the Digit span test, the Continuous performance test, the Rey auditory & visual learning test, the Complex figure test, the Verbal fluency test, the Wisconsin card sorting test and the Finger tapping test. The effects of subsyndromal symptomatology and general intelligence score were controlled. Results Schizophrenia patients' group showed more significant impairment than other groups in verbal memory (learning, immediate recall, delayed recall), visual memory (copy, immediate recall, delayed recall) and cognitive flexibility domains. The family group and the patient group commonly performed significantly worse than healthy controls in working memory and verbal fluency (category) tests. There were no differences in sustained attention, psychomotor performance. Conclusions Our research shows that the deficit in working memory and verbal fluency could be strong candidates of endophenotypic marker in schizophrenia.
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등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Green MF / 2000 / Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? / Schizophr Bull 26:119~136
Caspi A / 2003 / Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode / Schizophr Res 65:87~94
Szöke A / 2008 / Longitudinal studies of cognition in schizophrenia : meta-analysis / Br J Psychiatry 192:248~257
Heinrichs RW / 1998 / Neurocognitive deficit in schizophrenia : a quantitative review of the evidence / Neuropsychology 12:426~445
Buchanan RW / 2005 / A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia / Schizophr Bull 31:5~19
Caspi A / 2003 / Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode / Schizophr Res 65:87~94
Szöke A / 2008 / Longitudinal studies of cognition in schizophrenia : meta-analysis / Br J Psychiatry 192:248~257
Heinrichs RW / 1998 / Neurocognitive deficit in schizophrenia : a quantitative review of the evidence / Neuropsychology 12:426~445
Buchanan RW / 2005 / A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia / Schizophr Bull 31:5~19
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