지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives We reviewed cellular and synaptic dysconnectivity, disturbances in micro- and macro- circuitries, and neurodevelopmentally-derived disruptions of neural connectivity in the pathogenesis of schizophrenia. Method We reviewed the selected articles about disturbances in neural circuits which had been proposed as a pathogenetic mechanism of schizophrenia. Results The literature review reveals that schizophrenia may be a disease related to disturbance in neurodevelopmental mechanism, shown as 'a misconnection syndrome of neural circuit or neural network'. In descriptive psychopathological view, definition of a disorder of brain connectivity has limitation to explain other aspects of schizophrenia including deterministic strictness in thought process. Conclusion Schizophrenia is considered as a disorder of brain connectivity as well as a neurodevelopmental disorder related with genetic and environmental factors. We could make a suggestion that "JoHyeonByung (attunement disorder)" denotes the disturbances of psychic fine-tuning which correspond to the neural correlates of brain dysconnectivity metaphorically.
목차
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참고문헌 (45)
참고문헌 신청
Salloway SP / 2002 / Introduction to functional neural circuitry, In Brain circuitry and signaling in psychiatry: Basic science and clinical implications / American Psychiatric Publishing Inc :1~29
Klempan TA / 2004 / Genes and brain development, In Neurodevelopment and schizophrenia / Cambridge University Press :3~34
Andreasen NC / 1999 / Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms / Biol Psychiatry 46:908~920
Wernicke C / 1906 / Grundrisse der Psychiatrie / Thieme
Bleuler E / 1911 / Dementia Praecox or the Group of Schizophrenias. English Translation 1961 / International Universities Press;
Klempan TA / 2004 / Genes and brain development, In Neurodevelopment and schizophrenia / Cambridge University Press :3~34
Andreasen NC / 1999 / Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms / Biol Psychiatry 46:908~920
Wernicke C / 1906 / Grundrisse der Psychiatrie / Thieme
Bleuler E / 1911 / Dementia Praecox or the Group of Schizophrenias. English Translation 1961 / International Universities Press;
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