지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives Although antipsychotic drug clozapine has superior efficacy, this is hampered by metabolic side effects such as weight gain and diabetes. Recent studies demonstrate that clozapine induces insulin resistance. However, the identity and location of insulin resistance induced by clozapine has not been clarified. In this study, the effect of clozapine on central insulin response was investigated in rats. Methods Male Sprague-Dawley rats received intraperitoneal injection of clozapine or vehicle, which was followed by intracerebroventricular injection of insulin or its vehicle. The effects of clozapine on insulin-induced changes in blood glucose level and Akt phosphorylation in hypothalamus were investigated. Results Intraperitoneal injection of clozapine (20 mg/kg) increased blood glucose in rats. Intracerebroventricular injection of insulin reduced blood glucose in rats, which was blunted by pretreatment of clozapine. Accompanied with the antagonistic effect of clozapine to central insulin action in terms of blood glucose, clozapine inhibited the insulin-induced phosphorylation of Akt at Ser473 in rat hypothalamus. Conclusion Administration of clozapine inhibited the central insulin-induced changes in blood glucose and Akt phosphorylation in rat hypothalamus. These findings suggest that hypothalamus could be the site of action for the clozapine-induced insulin resistance.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Newcomer JW / 2007 / Metabolic considerations in the use of antipsychotic medications: a review of recent evidence / J Clin Psychiatry 68(Suppl 1):20~27
Henderson DC / 2000 / Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study / Am J Psychiatry 157:975~981
Henderson DC / 2006 / Glucose metabolism in patients with schizophrenia treated with olanzapine or quetiapine: a frequently sampled intravenous glucose tolerance test and minimal model analysis / J Clin Psychiatry 67:789~797
Henderson DC / 2005 / Clozapine, diabetes mellitus, hyperlipidemia, and cardiovascular risks and mortality: results of a 10-year naturalistic study / J Clin Psychiatry 66:1116~1121
Sernyak MJ / 2002 / Association of diabetes mellitus with use of atypical neuroleptics in the treatment of schizophrenia / Am J Psychiatry 159:561~566
Henderson DC / 2000 / Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study / Am J Psychiatry 157:975~981
Henderson DC / 2006 / Glucose metabolism in patients with schizophrenia treated with olanzapine or quetiapine: a frequently sampled intravenous glucose tolerance test and minimal model analysis / J Clin Psychiatry 67:789~797
Henderson DC / 2005 / Clozapine, diabetes mellitus, hyperlipidemia, and cardiovascular risks and mortality: results of a 10-year naturalistic study / J Clin Psychiatry 66:1116~1121
Sernyak MJ / 2002 / Association of diabetes mellitus with use of atypical neuroleptics in the treatment of schizophrenia / Am J Psychiatry 159:561~566
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