지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Venlafaxine is among the most widely prescribed antidepressants. It is extensively metabolized to O-desmethylvenlafaxine via cytochrome P450 (CYP) 2D6. We report a case of acute toxic hepatitis resulting from venlafaxine in a 54-year-old woman with pain disorder. During venlafaxine treatment, laboratory tests revealed elevated liver enzymes with a maximum of 169 IU/L for aspartate transaminase (AST) and 166 IU/L for alanine transaminase (ALT). AST and ALT levels returned to normal after 6 days of discontinuation of venlafaxine. The patient was finally diagnosed with acute toxic hepatitis through liver biopsy. This case indicates the importance that clinicians should be aware of the hepatotoxicity of venlafaxine in practice.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Holliday SM / 1995 / Venlafaxine. A review of its pharmacology and therapeutic potential in depression / Drugs 49:280~294
Rotzinger S / 1999 / Metabolism of some “second”- and “fourth”-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine / Cell Mol Neurobiol 19:427~442
Courtney DB / 2004 / Selective serotonin reuptake inhibitor and venlafaxine use in children and adolescents with major depressive disorder: a systematic review of published randomized controlled trials / Can J Psychiatry 49:557~563
Rudolph RL / 2002 / Achieving remission from depression with venlafaxine and venlafaxine extended release: a literature review of comparative studies with selective serotonin reuptake inhibitors / Acta Psychiatr Scand Suppl :24~30
Dierick M / 1997 / A review of the efficacy and tolerability of venlafaxine / Eur Psychiatry 12(4):307s~313s
Rotzinger S / 1999 / Metabolism of some “second”- and “fourth”-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine / Cell Mol Neurobiol 19:427~442
Courtney DB / 2004 / Selective serotonin reuptake inhibitor and venlafaxine use in children and adolescents with major depressive disorder: a systematic review of published randomized controlled trials / Can J Psychiatry 49:557~563
Rudolph RL / 2002 / Achieving remission from depression with venlafaxine and venlafaxine extended release: a literature review of comparative studies with selective serotonin reuptake inhibitors / Acta Psychiatr Scand Suppl :24~30
Dierick M / 1997 / A review of the efficacy and tolerability of venlafaxine / Eur Psychiatry 12(4):307s~313s
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