지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 393 - 401 (9page)
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초록· 키워드
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Objectives: Endotoxins in dust generated in occupational settings is known to contribute to the occurrence of respiratory illness among workers. The relationship between the level of endotoxins in total dust or respirable particulates collected from swine farms and immunological markers related with respiratory allergy was evaluated among swine husbandry workers. Materials and Methods: Peripheral blood samples were collected from ten workers at ten swine farms at Gyeonggi province, Korea. Peripheral mononuclear cells were stimulated with phorbol 12-myristate 13-acetate and ionomycin for 48 hours. The levels of various cytokines produced at culture supernatants were determined using a commercially available ELISA kit. The concentration of particulate matter($PM_{10}$) in the indoor air of the swine farms was evaluated using a PVC membrane filter and mini volume air sampler, and endotoxin levels in the dust were measured by Limulus Amebocyte Lysate Kinetic QCL method. Results: Levels of endotoxins in the total dust were categorized into high(geometric mean: $109.35EU/m^3$) and low concentrations (geometric mean: $0.95EU/m^3$) for five swine farms. Interleukin-4 levels were higher in the high endotoxin group than in the low endotoxin group, while interferon-${\gamma}$ levels were lower in the high endotoxin group than in the low endotoxin group. The ratio (interferon-${\gamma}$ to interleukin-4), indicating immunologic skewedness against allergic reactivities, was lower in the high endotoxin group($1.15{\pm}0.60$) than the low endotoxin group($3.09{\pm}2.38$). In addition, the level of interleukin-13, another cytokine contributing to the occurrence of allergic responses, was significantly higher in the at the high endotoxin group($1.12{\pm}0.37ng/m{\ell}$) than in the low endotoxin group($0.37{\pm}0.04ng/m{\ell}$). Hematologic assessment showed significantly lower cellularity in the number of total leukocytes, neutrophils, and eosinophils in the high endotoxin group than in the low endotoxin group. Conclusions: Even though a sufficient number of swine workers and farms were not investigated, this study generlly suggests that the immunological function of swine farm workers exposed to high levels of endotoxin could be modulated toward allergic reactivities.
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참고문헌 (31)
참고문헌 신청
Abbas AK / 2007 / Cellular and Molecular Immunology / Saunders Elsevier :441~462
ACGIH / 2010 / TLVs® and BEIs® / The American Conference of Governmental Industrial Hygienists :74
Akdis M / 2011 / Interleukins, from 1 to 37, and interferon- γ:receptors, functions, and roles in diseases / J Allergy Clin Immunol 127:701~721
Basinas I / 2012 / Exposure to inhalable dust and endotoxin among Danish livestock farmers:results from the SUS cohort study / J Environ Monit 14(2):604~614
Cambra-López M / 2010 / Airborne particulate matter from livestock production systems: a review of an air pollution problem / Environ Poll 158:1~17
ACGIH / 2010 / TLVs® and BEIs® / The American Conference of Governmental Industrial Hygienists :74
Akdis M / 2011 / Interleukins, from 1 to 37, and interferon- γ:receptors, functions, and roles in diseases / J Allergy Clin Immunol 127:701~721
Basinas I / 2012 / Exposure to inhalable dust and endotoxin among Danish livestock farmers:results from the SUS cohort study / J Environ Monit 14(2):604~614
Cambra-López M / 2010 / Airborne particulate matter from livestock production systems: a review of an air pollution problem / Environ Poll 158:1~17
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