지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 218 - 224 (7page)
이용수
초록· 키워드
오류제보하기
Organophosphorus compounds are irreversible inhibitors of cholinesterase enzyme. Exposure causes a progression of toxic signs, including hypersecretion, tremor, convulsion, respiratory distress, epileptiform seizure, brain injuries and death. To protect brain injuries, administration of diazepam as a neuroprotectant is now considered essential for severely exposed nerve agent casualties. However, studies have shown diazepam to provide less than total protection against the neuropathological consequences of nerve agent exposure. In this context, extensive studies have been carried out to find out effective alternative drugs to protect brain from epileptiform seizures induced by organophosphate compounds intoxication. It has been reported that a combination of carbamate and anticholinergic or antiglutamatergic can be a very effective medical countermeasure in dealing with the threat of organophosphorous poisoning. In this study, experimental animals including rats and guinea pigs were implanted with microelectrodes on their brain sculls, and treated with various centrally acting drugs such as physostigmine and procyclidine prior to soman challenge, and then its electroencephalography(ECoG) was monitored to see anticonvulsant effects of the drugs. It was found that seizure activities in ECoG were not always in proportion to clinical signs induced by soman intoxication, and that combinative pretreatment with physostigmine plus procyclidine effectively stopped the seizures induced by organophosphorous poisoning.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
McDonough, J. H / 1993 / Pharmacological Modulation of Soman-Induced Seizures / Neurosci. Biobehav. Rev 17:203~215
Shih, T. M / 1991 / Anti- Convulsants for Poisoning by the Organophosphorus Compound Soman : Pharmacological Mechanisms / Neurosci. Biobehav. Rev 15:349~362
Kim, Y.-B / 1999 / Organophosphate-Induced Brain Injuries : Delayed Apoptosis Mediated by Nitric Oxide / Environ. Toxicol. Pharmacol 7:147~152
McDonough, J. H / 1989 / Atropine and Diazepam Therapy Protects Against Soman-Induced Neural and Cardiac Pathology / Fund. Appl. Toxicol 13:256~276
Tryphonas, L / 1995 / Histomorphogenesis of Soman-Induced Encephalocardiomyopathy in Sprague-Dawley Rats / Toxicol. Pathol 23:393~409
Shih, T. M / 1991 / Anti- Convulsants for Poisoning by the Organophosphorus Compound Soman : Pharmacological Mechanisms / Neurosci. Biobehav. Rev 15:349~362
Kim, Y.-B / 1999 / Organophosphate-Induced Brain Injuries : Delayed Apoptosis Mediated by Nitric Oxide / Environ. Toxicol. Pharmacol 7:147~152
McDonough, J. H / 1989 / Atropine and Diazepam Therapy Protects Against Soman-Induced Neural and Cardiac Pathology / Fund. Appl. Toxicol 13:256~276
Tryphonas, L / 1995 / Histomorphogenesis of Soman-Induced Encephalocardiomyopathy in Sprague-Dawley Rats / Toxicol. Pathol 23:393~409
이 논문의 저자 정보
최근 본 자료
댓글(0)
0