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논문 기본 정보

자료유형
학술저널
저자정보
유헌숙 (Dept. of Pathology, College of Oriental Medicine, Daejeon University) 김선빈 (Traditional and Biomedical Research Center[TBRC], Daejeon University) 송향희 (Dept. of Health Skincare, Byuksung College) 지중구 (Dept. of Oriental health care, Joongbu University) 박지원 (Dept. of Pathology, College of Oriental Medicine, Daejeon University) 김동희 (Dept. of Pathology, College of Oriental Medicine, Daejeon University)
저널정보
대전대학교 한의학연구소 논문집 : 대전대학교 한의학연구소. 한의학편 논문집 : 대전대학교 한의학연구소. 한의학편 제21권 제1호
발행연도
2012.1
수록면
53 - 63 (11page)

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Objectives : The aim of this study was to investigate the effect of Chunghwatang (CHT) for atopic dermatitis. Methods : CHT, a verified anti-oxidant and anti-inflammatory effect, was treated in atopic dermatitis animal model to investigate cytokine levels and immunoglobulin production. Results : Clinical skin index was 47.1%, suggesting significant efficacy of CHT in atopic dermatitis treatment. Serum IL-4, IL-6, IL-13, TNF-${\alpha}$ and histamine productions were significantly decreased to 52.3%, 61.8%, 68.0%, 37.4%, and 46.6%, respectively. The production of IL-5 was decreased to 33.3%. The increase of Immunoglobulin IgG1 production along with IgE through the interaction of IgE and IL-4 induced by IL-4 and IL-13 were measured as 20.7% and 23.4%, respectively. Conclusions : The results above, along with the in vitro test results, strongly supports the CHT samples as effective immunomodulator in AD treatments, suggesting its use in clinical practice and basic information for EBM.

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