Latest status of the clinical and industrial applications of cell sheet engineering and regenerative medicine

Egami, Mime; Haraguchi, Yuji; Shimizu, Tatsuya; Yamato, Masayuki; Okano, Teruo

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자료유형: 학술저널

저자정보: Egami, Mime (Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University) Haraguchi, Yuji (Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University) Shimizu, Tatsuya (Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University) Yamato, Masayuki (Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University) Okano, Teruo (Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University)

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제37권 제1호

발행연도: 2014.1

수록면: 96 - 106 (11page)

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Cell sheet engineering, which allows tissue engineering to be realized without the use of biodegradable scaffolds as an original approach, using a temperature-responsive intelligent surface, has been applied in regenerative medicine for various tissues, and a number of clinical studies have been already performed for life-threatening diseases. By using the results and findings obtained from the initial clinical studies, additional investigative clinical studies in several tissues with cell sheet engineering are currently in preparation stage. For treating many patients effectively by cell sheet engineering, an automated system integrating cell culture, cell-sheet fabrication, and layering is essential, and the system should include an advanced three-dimensional suspension cell culture system and an in vitro bioreactor system to scale up the production of cultured cells and fabricate thicker vascularized tissues. In this paper, cell sheet engineering, its clinical application, and further the authors' challenge to develop innovative cell culture systems under newly legislated regulatory platform in Japan are summarized and discussed.

#Cell sheet engineering #Clinical trial #Pharmaceutical Affairs Law #Regenerative medicine #Temperature-responsive culture surface #Three-dimensional tissue

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