지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Zinc oxide nanoparticles (ZnONPs) are widely used in a variety of products and cosmetic products including paper, paints, plastics and sunscreen. However, information on the safety of ZnONPs are not enough and many publications suggest possible toxic effects on environmental and human health. Furthermore, physico-chemical characteristics of nanoparticles makes it hard to test toxicity using the test guidelines of chemicals adopted by regulatory bodies. In this study, stability of ZnONPs was investigated using different types of isotonic solution, which is important in the toxicity study of intravenous route. Precipitation, aggregation, size, zeta potential and morphology of ZnONPs were evaluated with different times and concentrations. Precipitation of ZnONPs were observed in ionic isotonic solution including phosphate-buffered saline, Kreb's-Ringer solution, physiological salt solution and cell culture media of DMEM (Dulbecco's Modified Eagle's Medium) with 10% fetal bovine serum. On the other hand, they were stable without precipitation in non-ionic isotonic solution such as 5% glucose and 2% glycerol, respectively, which are biocompatible for intravenous injection. The average size of ZnONPs in 5% glucose and 2% glycerol was stably maintained, which is less than 30 nm and very similar as that in water dispersion of ZnONPs, provided by the manufacturer. The stability was maintained during the experimental period of 5 days and diluted state up to 15,000 ppm. These data suggest that 5% glucose and 2% glycerol solution can be used for the vehicles of ZnONPs in the toxicity study of intravenous injection route.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Nohynek, G. J / 2012 / Nano-sized cosmetic formulations or solid nanoparticles in sunscreens: a risk to human health? / Arch. Toxicol 86:1063
Hackenberg, S / 2012 / Dermal toxicity of ZnO nanoparticles: a worrying feature of sunscreen? / Nanomedicine 7:461
Kao, Y. Y / 2012 / Zinc oxide nanoparticles interfere with zinc ion homeostasis to cause cytotoxicity / Toxicol. Sci 125:462
Sharma, V / 2011 / Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes / J. Nanosci. Nanotechnol 11:3782
Roy, R / 2011 / Cytotoxicity and uptake of zinc oxide nanoparticles leading to enhanced inflammatory cytokines levels in murine macrophages: comparison with bulk zinc oxide / J. Biomed. Nanotechnol 7:110
Hackenberg, S / 2012 / Dermal toxicity of ZnO nanoparticles: a worrying feature of sunscreen? / Nanomedicine 7:461
Kao, Y. Y / 2012 / Zinc oxide nanoparticles interfere with zinc ion homeostasis to cause cytotoxicity / Toxicol. Sci 125:462
Sharma, V / 2011 / Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes / J. Nanosci. Nanotechnol 11:3782
Roy, R / 2011 / Cytotoxicity and uptake of zinc oxide nanoparticles leading to enhanced inflammatory cytokines levels in murine macrophages: comparison with bulk zinc oxide / J. Biomed. Nanotechnol 7:110
이 논문의 저자 정보
최근 본 자료
댓글(0)
0