Novel arylhydrazone derivatives bearing a rhodanine moiety: synthesis and evaluation of their antibacterial activities

Li, Wei; Zheng, Chang-Ji; Sun, Liang-Peng; Song, Ming-Xia; Wu, Yan; Li, Yin-Jing; Liu, Yi; Piao, Hu-Ri

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자료유형: 학술저널

저자정보: Li, Wei (Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy) Zheng, Chang-Ji (Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy) Sun, Liang-Peng (Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy) Song, Ming-Xia (Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy) Wu, Yan (Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy) Li, Yin-Jing (Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, Yanbian University College of Pharmacy) Liu, Yi (Key Laboratory of Natural Re) Piao, Hu-Ri

저널정보: 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제37권 제7호

발행연도: 2014.1

수록면: 852 - 861 (10page)

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A series of arylhydrazone derivatives bearing a rhodanine moiety have been synthesized, characterized, and evaluated as antibacterial agents. Some of these compounds showed potent antibacterial activities against several different strains of Gram-positive bacteria, including multidrug-resistant clinical isolates. Of the compounds tested, IIk and IIIk were identified as the most effective, with minimum inhibitory concentration values of $2-4{\mu}g/mL$ against multidrug-resistant Gram-positive organisms, including methicillin-resistant and quinolone-resistant Staphylococcus aureus. None of the compounds exhibited any activity against the Gram-negative bacteria Escherichia coli 1356 at $64{\mu}g/mL$.

#Arylhydrazone #Rhodanine #Antibacterial activity #Methicillin-resistant Staphylococcus aureus #Quinolone-resistant Staphylococcus aureus

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Li, Wei

소속기관 Department of Orthopedics, Binzhou Central Hospital

주요연구분야 의약학 > 약학

논문수 4 이용수 1

Zheng, Chang-Ji