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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제6호
- 발행연도
- 2008.1
- 수록면
- 758 - 763 (6page)
이용수
초록· 키워드
오류제보하기
This study examnined the effects of tanshinone derivatives (tanshinone I, cryptotanshinone, 15,16-dihydrotanshinone I) on prostaglandin (PG) and nitric oxide (NO) metabolism in an attempt to establish their anti-inflammatory mechanisms and to present a scientific rationale for the use of Salvia miltiorrhiza (danshen) in inflammatory conditions. From lipopolysaccharidetreated RAW 264.7 cells, cyclooxygenase-2 (COX-2)-mediated $PGE_2$ production was inhibited by tanshinone I, cryptotanshinone and 15,16-dihydrotanshinone I, while only cryptotanshinone and 15,16-dihydrotanshinone I inhibited inducible NO synthase (iNOS)-mediated NO synthesis at $1-50\;{\mu}M$. Particularly, cryptotanshinone was found to be a down-regulator of proinflammatory molecule expression, including COX-2 and iNOS. The electrophoretic mobility shift assay showed that cryptotanshinone and 15,16-dihydrotanshinone I also inhibited the activation of the transcription factors, such as nuclear transcription factor-${\kappa}B$ and activator protein-1. Moreover, cryptotanshinone exhibited in vivo anti-inflammatory activity against carrageenaninduced paw edema in rats. Overall, these results provide additional scientific rationale for the anti-inflammatory use of danshen in Chinese medicine. Especially, cryptotanshinone and 15,16-dihydrotanshinone I are important constituents.
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Salvia Miltiorrhiza-induced Regulation of Osteoclastogenesis and the Determination of Components-Tanshinone I, Tanshinone IIA, Cryptotanshinone and Dihydrotanshinone using LC-MS/MS
대한임상약리학회 학술대회
2006 .01
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Molecular Mechanisms of Inhibitory Activities of Tanshinones on Lipopolysaccharide-Induced Nitric Oxide Generation in RAW 264.7 Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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Inhibition of Osteoclast Differentiation by Tanshinones from the Root of Salvia miltiorrhiza Bunge
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
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Effects of Tanshinone I Isolated from Salvia miltiorrhiza Bunge on Arachidonic Acid Metabolism and In Vivo Inflammatory Responses
대한약학회 학술대회
2000 .01
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단삼 유래 단일 물질 cryptotanshione의 전립선 암주에서의 HIF-1alpha와 STAT3 억제를 통한 신생혈관억제효과
동의생리병리학회지
2012 .08
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15,16-Dihydrotanshinone I, a Major Component from Salvia Miltiorrhiza Bunge(Dansham), Inhibits Rabbit Platelet Aggregation by Suppressing Intracellular Calcium Mobilization
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
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단삼 유래 Tanshinone IIA가 3T3-L1 세포의 아포토시스 유도와 지방형성 억제에 미치는 영향
동의생리병리학회지
2009 .12
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Effects of Tanshinone IIA on the Hepatotoxicity and Gene Expression Involved in Alcoholic Liver Disease
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
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Inhibitory Activity of Diacylglycerol Acyltransferase by Tanshinones from the Root of Salvia miltiorrhiza
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
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Tanshinone 단삼성분의 전신성 캔디다증에 대한 항균효과
약학회지
2013 .01
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Anti-osteoporotic effect of Salvia miltiorrhiza extracts
동의생리병리학회지
2003 .10
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단삼 유래 단일 물질 cryptotanshione의 전립선 암주에서의 HIF-1alpha와 STAT3 억제를 통한 신생혈관억제효과
동의생리병리학회지
2012 .01
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RAW 264.7 Cell에서 세이지에 의한 염증성 Cytokine 및 iNOS억제 효과
약학회지
2004 .01
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Inhibition of Nitric Oxide Production from lipopolysaccharide-Treated RAW 264.7 Cells by Synthetic Flavones：Structure-Activity Relationship and Action Mechanism
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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Tanshinones from Salvia miltiorrhiza inhibits mast cell degranulation by blocking the tyrosine phosphyorylation of MAPK
대한약학회 학술대회
2000 .01
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CURCUMIN INHIBITS EXPRESSION OF CYCLOOXYGENASE-2 AND INDUCIBLE NITRIC OXIDE SYNTHASE AND ACTIVATION OF NF-kappa B AND AP-1 TRANSCRIPTION FACTORS
대한약학회 학술대회
2000 .01
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단삼 등 천연물의 항암작용
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1999 .01
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단삼 유래 Tanshinone IIA가 3T3-L1 세포의 아포토시스 유도와 지방형성 억제에 미치는 영향
동의생리병리학회지
2009 .01
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Ceramide analogs inhibit inducible nitric oxide synthase expression and nitric oxide production in interferon-gamma and lipopolysaccharide-stimulated RAW 264.7 macrophages.
대한약학회 학술대회
2002 .01
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