지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Phentermine (PT) and phenmetrazine (PM) have been widely used as anti-obesity drugs. These drugs should be used with caution due to its close relation to amphetamine in its structure and toxicity. PT and PM, amphetamine-type anorectics, have recently been considered as alternatives for methamphetamine abuse in Korea. In addition, the misuse and abuse of PT and PM obtained by illegal sources such as the internet become a serious social problem. In the present study, a simultaneous detection and quantification method for determining PT and PM in human urine was developed and validated according to the international guidelines. The urine samples were screened using a fluorescence polarization immunooassay and analyzed by gas chromatography mass spectrometry (GC-MS) after extraction using automatic solid phase extraction (SPE) with a mixed-mode cation exchange cartridge and derivatization with pentafluoropropionic anhydride (PFPA). The validation results for selectivity, linearity, limits of detection (LOD) and quantification (LOQ), intra- and inter-assay precision and accuracy and recovery were satisfactory. The validated method was successfully applied to authentic urine samples collected from 38 drug abuse suspects. PT and/or PM were identified with or without methamphetamine in urine samples. Abuse of PT and PM have increased continuously in Korea, therefore, closer supervision of the inappropriate use of anoretics is necessary.
목차
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참고문헌 (11)
참고문헌 신청
Abenheim, L / 1996 / Appetite-suppressant drugs and the risk of primary pulmonary hypertension / New Engl. J. Med 335:609
Lee, S / 2011 / Detection of phentermine in hair samples from drug suspects / Forensic Sci Int 207:e5
Jonsson, J / 1996 / A convenient derivatization method for the determination of amphetamine and related drugs in urine / J. Forensic Sci 41:148
Marin, S. J / 2009 / Cross-reactivity of phentermine with an immunoassay designed to detect amphetamine in a meconium specimen / Clin Chem 55:589
Palmer, R. B / 2000 / Simultaneous determination of fenfluramine and phentermine in urine using gas chromatography mass spectrometry with pentafluoropropionic anhydride derivatization / Ther Drug Monit 22:418
Lee, S / 2011 / Detection of phentermine in hair samples from drug suspects / Forensic Sci Int 207:e5
Jonsson, J / 1996 / A convenient derivatization method for the determination of amphetamine and related drugs in urine / J. Forensic Sci 41:148
Marin, S. J / 2009 / Cross-reactivity of phentermine with an immunoassay designed to detect amphetamine in a meconium specimen / Clin Chem 55:589
Palmer, R. B / 2000 / Simultaneous determination of fenfluramine and phentermine in urine using gas chromatography mass spectrometry with pentafluoropropionic anhydride derivatization / Ther Drug Monit 22:418
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