지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The neuroprotective effects of herbal ethanol extract (GP-EX) from Gynostemma pentaphyllum on dopamine neurons in animal model of Parkinson's disease (PD) were investigated. Rats and mice were administered with rotenone (2.5 mg/kg) for 28 days and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg) for 5 days for the PD models, respectively and the animals were simultaneously treated with GP-EX (30 mg/kg, daily). After preparing the PD models, the animals were also administered with L-DOPA (10 mg/kg) for 14 days with or without GP-EX treatment. Treatment with GP-EX (30 mg/kg) inhibited the rotenone- and MPTP-induced neurotoxic effects in dopamine neurons of rats or mice, which was determined by the numbers of tyrosine hydroxylase-immunohistochemical staining survival cells, as well as the levels of dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid. GP-EX (30 mg/kg) also showed the protective effects on neurotoxicity which was induced by long-term administration of L-DOPA (10 mg/kg) in rotenone- and MPTP-induced animal model of PD. The used doses of GP-EX (30 mg/kg) did not produce any signs of toxicity, such as weight loss, diarrhea, or vomiting, in rats and mice during the treatment periods. These results suggest that GP-EX has the protective functions against chronic L-DOPA-induced neurotoxic reactions in dopamine neurons of rotenone- and MPTP-induced animal model of PD. Therefore, the natural GP-EX may be beneficial in the prevention of PD progress and L-DOPA-induced neurotoxicity in PD patients.
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참고문헌 (50)
참고문헌 신청
Kim, Y. J / 2004 / Etiology and pathogenesis of Parkinson's disease. J. Korean Neurol / Assoc 22:421
Migliore, L / 2009 / Environmental-induced oxidative stress in neurodegenerative disorders and aging / Mutat. Res 31:73
Olanow, C. W / 2001 / An algorithm (decision tree) for the management of Parkinson's disease treatment guidelines / Neurology 56:1
Cheng, N / 1996 / Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons / Brain Res 16:278
Yacoubian, T. A / 2009 / Yacoubian, T. A. and Standaert, D. C. : Targets for neuroprotection in Parkinson's disease / Biochim. Biophys. Acta 1792:676
Migliore, L / 2009 / Environmental-induced oxidative stress in neurodegenerative disorders and aging / Mutat. Res 31:73
Olanow, C. W / 2001 / An algorithm (decision tree) for the management of Parkinson's disease treatment guidelines / Neurology 56:1
Cheng, N / 1996 / Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons / Brain Res 16:278
Yacoubian, T. A / 2009 / Yacoubian, T. A. and Standaert, D. C. : Targets for neuroprotection in Parkinson's disease / Biochim. Biophys. Acta 1792:676
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