지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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This study was to elucidate the anti-inflammatory activities of a methanol extract derived from the fermented bark of Dioscoreae batatas on LPS-induced activation in macrophages. It was fermented with Lactobacillus fermentum and L. plantarum and then analyzed to identify the contents of methanol extract and diosgenin. The fermented product showed 3-fold increase in the extraction yield by methanol, and 1.8-fold increase in diosgenin contents, compared to that from the dried bark of D. batatas. Although the methanol extract from the unfermented D. batatas inhibited lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and TNF-${\alpha}$ in J774 A.1 cells, the methanol extract from the fermented product revealed significantly the enhanced the inhibitory activities on LPS-induced production of NO and TNF-${\alpha}$. Taken together, our results indicate that fermentation of bark of D. batatas elevates the functional activity inhibiting macrophage activation through the increase of the content of anti-inflammatory compounds. Thus, its methanol extract may be useful as a functional material for the therapy of inflammatory diseases.
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참고문헌 (41)
참고문헌 신청
Flora of Korea Editorial Committee / 2007 / The Genera of Vascular Plants of Korea / Academy Publishing Co., Seoul. Korea :1336
생약학교재편찬위원회 / 2007 / 생약학 / 동명사 :250
Jang, S. M. / 1999 / Botany of Herbal Medicine Resources / Hakmun Publishing Ltd :299
양민혜 / 2009 / 한국, 중국, 일본에서 자생하는 ‘ 마 ’ 속 식물의 화학 성분과 활성 / 생약학회지 40(4):257~279
Sautour, M. / 2004 / A new phenanthrene glycoside and other constituents from Dioscorea opposita / Chem. Pharm. Bull 52:1235
생약학교재편찬위원회 / 2007 / 생약학 / 동명사 :250
Jang, S. M. / 1999 / Botany of Herbal Medicine Resources / Hakmun Publishing Ltd :299
양민혜 / 2009 / 한국, 중국, 일본에서 자생하는 ‘ 마 ’ 속 식물의 화학 성분과 활성 / 생약학회지 40(4):257~279
Sautour, M. / 2004 / A new phenanthrene glycoside and other constituents from Dioscorea opposita / Chem. Pharm. Bull 52:1235
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