지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Nonalcoholic steatohepatitis(NASH) is serious metabolic disease related to fatty acid. According to "two hit theory", fatty acid-induced oxidative stress is important factor to progress nonalcoholic steatohepatitis from steatosis. In this study, we evaluated stearic acid induced oxidative stress in human hepatocarcinoma SK-Hep-1 cell. Cell viability, reactive oxygen species (ROS) production, glutathione (GSH), malondialdehyde and expression of antioxidant enzymes were determined at various time-points and concentrations of stearic acid. At 0.2 mM, non-toxic concentration, of stearic acid, production of ROS was significantly increased at 24 hours and the level of GSH was significantly decreased. Expression of superoxide dismutase-1 and 2 was slightly increased in 0.2 mM stearic acid at 24 hours. These results represent that the non-toxic concentration of stearic acid resulted in oxidative stress, suggesting that stearic acid may play a critical role in development of steatohepatitis.
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참고문헌 (30)
참고문헌 신청
Gasbarrini, G. / 2005 / Nonalcoholic fatty liver disease: defining a common problem / Eur. Rev. Med. Pharmacol. Sci 9:253
Bradbury, M. W. / 2006 / Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis / Am. J. Physiol. Gastrointest. Liver Physiol 290:194
Koruk, M. / 2003 / Serum lipids, lipoproteins and apolipoproteins levels in patients with nonalcoholic steatohepatitis / J. Clin. Gastroenterol 37:177
Mccullough, A. J. / 2006 / Pathophysiology of nonalcoholic steatohepatitis / J. Clin. Gastroenterol 40:17
Clark, J. M. / 2006 / The epidemiology of nonalcoholic fatty liver disease in adults / J. Clin. Gastroenterol 40:S5
Bradbury, M. W. / 2006 / Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis / Am. J. Physiol. Gastrointest. Liver Physiol 290:194
Koruk, M. / 2003 / Serum lipids, lipoproteins and apolipoproteins levels in patients with nonalcoholic steatohepatitis / J. Clin. Gastroenterol 37:177
Mccullough, A. J. / 2006 / Pathophysiology of nonalcoholic steatohepatitis / J. Clin. Gastroenterol 40:17
Clark, J. M. / 2006 / The epidemiology of nonalcoholic fatty liver disease in adults / J. Clin. Gastroenterol 40:S5
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